{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/79817"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/79817","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Chalcogenopyrylium Dyes for Multiplex Biosensing","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Rosch, Lauren; 0000-0002-6478-6415"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Detty, Michael","Chemistry"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-07-26T19:41:27Z","date_published":"2019-07-26T19:41:27Z","updated_at":"2026-07-27T19:05:19Z","subjects":["chemistry","organic chemistry"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/79817","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Detty, Michael","Chemistry"]},{"key":"dc:creator","label":"Author","values":["Rosch, Lauren; 0000-0002-6478-6415"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-07-26T19:41:27Z","2019","2019-05-16 14:19:11"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["chemistry","organic chemistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/79817"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","Surface enhanced Raman scattering (SERS) has gained recognition as a biomedical imaging technique because of its sensitivity and multiplexing capabilities. By sensing multiple disease biomarkers at once, early disease detection improves. Pyrylium dyes contain a highly modifiable scaffold that can be used to generate unique, spectroscopically distinguishable dyes with applications as SERS reporter molecules. High-binding affinity between a reporter molecule and the SERS substrate, typically a gold nanoparticle, can be achieved by functionalizing pyrylium dyes with high chalcogen content. Sum-frequency generation vibrational spectroscopy (SFG-VS) can be used to determine the binding angle between a dye and the gold surface. The position and location of the chalcogen atoms in pyrylium dyes affects their binding angle. A new library of chalcogenopyrylium dyes containing various combinations of 3-thienyl, 2,6-dimethylphenyl, and t-butyl substituents was synthesized and analyzed as potential SERS reporters for multiplex biosensing studies. These dyes are hypothesized to bind at a unique angle compared to previously investigated 2-thienyl pyryliums and will provide more insight into how structural modification affect binding surface coverage and SERS intensity."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Chalcogenopyrylium Dyes for Multiplex Biosensing"]}]}],"canonical_facts":{"dc:contributor":["Detty, Michael","Chemistry"],"dc:creator":["Rosch, Lauren; 0000-0002-6478-6415"],"dc:date":["2019-07-26T19:41:27Z","2019","2019-05-16 14:19:11"],"dc:description":["M.S.","Surface enhanced Raman scattering (SERS) has gained recognition as a biomedical imaging technique because of its sensitivity and multiplexing capabilities. By sensing multiple disease biomarkers at once, early disease detection improves. Pyrylium dyes contain a highly modifiable scaffold that can be used to generate unique, spectroscopically distinguishable dyes with applications as SERS reporter molecules. High-binding affinity between a reporter molecule and the SERS substrate, typically a gold nanoparticle, can be achieved by functionalizing pyrylium dyes with high chalcogen content. Sum-frequency generation vibrational spectroscopy (SFG-VS) can be used to determine the binding angle between a dye and the gold surface. The position and location of the chalcogen atoms in pyrylium dyes affects their binding angle. A new library of chalcogenopyrylium dyes containing various combinations of 3-thienyl, 2,6-dimethylphenyl, and t-butyl substituents was synthesized and analyzed as potential SERS reporters for multiplex biosensing studies. These dyes are hypothesized to bind at a unique angle compared to previously investigated 2-thienyl pyryliums and will provide more insight into how structural modification affect binding surface coverage and SERS intensity."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/79817"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["chemistry","organic chemistry"],"dc:title":["Chalcogenopyrylium Dyes for Multiplex Biosensing"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:19Z"}