{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/79813"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/79813","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Oxime Ligands for Fe(III) MRI Contrast Agents and for Sensing Fe(III) and Fe(II)","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Hove, Vusumuzi"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Morrow, Janet","Chemistry"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-07-26T18:37:13Z","date_published":"2019-07-26T18:37:13Z","updated_at":"2026-07-27T19:05:19Z","subjects":["chemistry"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/79813","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Morrow, Janet","Chemistry"]},{"key":"dc:creator","label":"Author","values":["Hove, Vusumuzi"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-07-26T18:37:13Z","2019","2019-05-07 20:12:34"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["chemistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/79813"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","Fe(III) macrocyclic complexes are a promising new alternative to Gd(III) complexes as MRI contrast agents. HOPO (hydroxypyridinones) ligands, a class of compounds that are heterocyclic and possess a hydroxyl group ortho to a ketone, are known iron chelators. Oxime ligands which bear similar properties to HOPOs were used in studies for ternary complex formation to impact the relaxivity and solubility of a Fe(III) macrocyclic contrast agent that contains an open coordination site. A library of HOPOs and oxime ligand L1 were used for this study. Oximes and HOPOs have been studied in literature and are known to bind to Fe(III) in a bidentate interaction leading to tris-complexes. Binding of oxime ligand L1 and Fe(II) in the presence and absence of O2 brings about an oxidative conversion of Fe(II) to Fe(III). Studies are presented in which UV-vis spectroscopic measurements are conducted to monitor the interaction between oxime ligand L1 and Fe(II) or Fe(III). In addition, Ga(III), in terms of its coordination chemistry, is an excellent diamagnetic analogue of the biologically important (but paramagnetic) Fe(III) ion and as such enables NMR investigations for structure elucidation purposes. Data will be presented to investigate the stoichiometry of the K3[Fe(L1**)3] complex and the interaction between Ga(III) and oxime ligand L1 under different conditions.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Oxime Ligands for Fe(III) MRI Contrast Agents and for Sensing Fe(III) and Fe(II)"]}]}],"canonical_facts":{"dc:contributor":["Morrow, Janet","Chemistry"],"dc:creator":["Hove, Vusumuzi"],"dc:date":["2019-07-26T18:37:13Z","2019","2019-05-07 20:12:34"],"dc:description":["M.S.","Fe(III) macrocyclic complexes are a promising new alternative to Gd(III) complexes as MRI contrast agents. HOPO (hydroxypyridinones) ligands, a class of compounds that are heterocyclic and possess a hydroxyl group ortho to a ketone, are known iron chelators. Oxime ligands which bear similar properties to HOPOs were used in studies for ternary complex formation to impact the relaxivity and solubility of a Fe(III) macrocyclic contrast agent that contains an open coordination site. A library of HOPOs and oxime ligand L1 were used for this study. Oximes and HOPOs have been studied in literature and are known to bind to Fe(III) in a bidentate interaction leading to tris-complexes. Binding of oxime ligand L1 and Fe(II) in the presence and absence of O2 brings about an oxidative conversion of Fe(II) to Fe(III). Studies are presented in which UV-vis spectroscopic measurements are conducted to monitor the interaction between oxime ligand L1 and Fe(II) or Fe(III). In addition, Ga(III), in terms of its coordination chemistry, is an excellent diamagnetic analogue of the biologically important (but paramagnetic) Fe(III) ion and as such enables NMR investigations for structure elucidation purposes. Data will be presented to investigate the stoichiometry of the K3[Fe(L1**)3] complex and the interaction between Ga(III) and oxime ligand L1 under different conditions.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/79813"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["chemistry"],"dc:title":["Oxime Ligands for Fe(III) MRI Contrast Agents and for Sensing Fe(III) and Fe(II)"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:19Z"}