{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/79417"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/79417","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"The Impact of Environmental and Genetic Insults on Adult and Developing Brain Oligodendrogenesis","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Freedman, David"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Stachowiak, Michal","Pathology and Anatomical Sciences"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-04-04T20:32:41Z","date_published":"2019-04-04T20:32:41Z","updated_at":"2026-07-27T19:05:16Z","subjects":["cellular","biology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/79417","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Stachowiak, Michal","Pathology and Anatomical Sciences"]},{"key":"dc:creator","label":"Author","values":["Freedman, David"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-04-04T20:32:41Z","2020","2019-01-17 00:23:53"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["cellular","biology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/79417"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","The focus of this dissertation was to understand how brain oligodendrocytes are affected by oxidative stress throughout development and in adulthood. The stressors ranged from the blast induced brain ischemia to neurodevelopmental disorders, all of which had been shown to affect the mitochondrial oxidative phosphorylation. Impaired mitochondrial function is accompanied by the loss of myelin indicative of impaired oligodendrocyte function. My overall hypothesis was that oligodendrocytes are damaged by oxidative stress but their precursor cells have significant regenerative capacity which may be augmented through stimulation of mitochondrial function. I have tested three postulates: 1) changes in myelin expression are associated with the loss of the central nervous system myelinating cells – oligodendrocytes; 2) the stem/progenitor cells in the brain neurogenic niches and/or local cortical oligodendrocyte precursor cells can increase the production of oligodendrocytes and thus compensate for the loss; and 3) the regeneration of oligodendrocytes can be augmented by pharmacological treatment with Phenylbutyrate, which targets oxidative phosphorylation and epigenetic control of the cell development."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["The Impact of Environmental and Genetic Insults on Adult and Developing Brain Oligodendrogenesis"]}]}],"canonical_facts":{"dc:contributor":["Stachowiak, Michal","Pathology and Anatomical Sciences"],"dc:creator":["Freedman, David"],"dc:date":["2019-04-04T20:32:41Z","2020","2019-01-17 00:23:53"],"dc:description":["Ph.D.","The focus of this dissertation was to understand how brain oligodendrocytes are affected by oxidative stress throughout development and in adulthood. The stressors ranged from the blast induced brain ischemia to neurodevelopmental disorders, all of which had been shown to affect the mitochondrial oxidative phosphorylation. Impaired mitochondrial function is accompanied by the loss of myelin indicative of impaired oligodendrocyte function. My overall hypothesis was that oligodendrocytes are damaged by oxidative stress but their precursor cells have significant regenerative capacity which may be augmented through stimulation of mitochondrial function. I have tested three postulates: 1) changes in myelin expression are associated with the loss of the central nervous system myelinating cells – oligodendrocytes; 2) the stem/progenitor cells in the brain neurogenic niches and/or local cortical oligodendrocyte precursor cells can increase the production of oligodendrocytes and thus compensate for the loss; and 3) the regeneration of oligodendrocytes can be augmented by pharmacological treatment with Phenylbutyrate, which targets oxidative phosphorylation and epigenetic control of the cell development."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/79417"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["cellular","biology"],"dc:title":["The Impact of Environmental and Genetic Insults on Adult and Developing Brain Oligodendrogenesis"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:16Z"}