{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/79414"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/79414","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"A Nanoliposomal Adjuvant Containing Cobalt-Porphyrin Phospholipids for Anthrax Protective Antigen","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Lin, Cuiyan"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Lovell, Jonathan","Biomedical Engineering"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-04-04T20:32:39Z","date_published":"2019-04-04T20:32:39Z","updated_at":"2026-07-27T19:05:16Z","subjects":["biomedical engineering"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/79414","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Lovell, Jonathan","Biomedical Engineering"]},{"key":"dc:creator","label":"Author","values":["Lin, Cuiyan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-04-04T20:32:39Z","2019","2019-01-16 20:52:39"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["biomedical engineering"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/79414"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","The application of only FDA-licensed human anthrax vaccine BioThrax is limited due to it requires five-immunization series over 18 months to induce protective immune response and annually booster to maintain immunity; In addition, the employment of trace LF and EF in the formulation rises concerns on side effects. In this study, we aim to develop an anthrax vaccine with liposomes containing cobalt-porphyrin-phospholipids (CoPoP) as adjuvant and anthrax protective antigen (PA) with his-tags as antigen that can provide long-term protective immunity rapidly with less immunization series and injection dose. His-tagged PA is able to bind to liposomes containing CoPoP spontaneously to form antigen-adjuvant nanoparticle with size around 150 nm. Mice immunization of PA conjugated with liposomes containing CoPoP and PHAD with immunization regimens (single immunization, and shortened prime-boost immunization intervals) induced high PA-neutralized IgG antibodies in 21 days and provided complete immune protection to mice against anthrax spore and lethal toxin challenge."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["A Nanoliposomal Adjuvant Containing Cobalt-Porphyrin Phospholipids for Anthrax Protective Antigen"]}]}],"canonical_facts":{"dc:contributor":["Lovell, Jonathan","Biomedical Engineering"],"dc:creator":["Lin, Cuiyan"],"dc:date":["2019-04-04T20:32:39Z","2019","2019-01-16 20:52:39"],"dc:description":["M.S.","The application of only FDA-licensed human anthrax vaccine BioThrax is limited due to it requires five-immunization series over 18 months to induce protective immune response and annually booster to maintain immunity; In addition, the employment of trace LF and EF in the formulation rises concerns on side effects. In this study, we aim to develop an anthrax vaccine with liposomes containing cobalt-porphyrin-phospholipids (CoPoP) as adjuvant and anthrax protective antigen (PA) with his-tags as antigen that can provide long-term protective immunity rapidly with less immunization series and injection dose. His-tagged PA is able to bind to liposomes containing CoPoP spontaneously to form antigen-adjuvant nanoparticle with size around 150 nm. Mice immunization of PA conjugated with liposomes containing CoPoP and PHAD with immunization regimens (single immunization, and shortened prime-boost immunization intervals) induced high PA-neutralized IgG antibodies in 21 days and provided complete immune protection to mice against anthrax spore and lethal toxin challenge."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/79414"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["biomedical engineering"],"dc:title":["A Nanoliposomal Adjuvant Containing Cobalt-Porphyrin Phospholipids for Anthrax Protective Antigen"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:16Z"}