{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/79412"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/79412","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Developing High Throughput Screening Methods for Co-crystal Photoactivity","abstract":"M.A.","abstract_html":"M.A.","abstract_has_math":false,"creators":["Tysoe, Andrew"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Benedict, Jason","Chemistry"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-04-04T20:32:37Z","date_published":"2019-04-04T20:32:37Z","updated_at":"2026-07-27T19:05:16Z","subjects":["physical chemistry"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/79412","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Benedict, Jason","Chemistry"]},{"key":"dc:creator","label":"Author","values":["Tysoe, Andrew"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-04-04T20:32:37Z","2019","2019-01-16 16:54:47"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["physical chemistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/79412"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.A.","Co-crystals are a subclass of crystals that are comprised of two or more different molecular components. A major theme in co-crystal research is that co-crystals display different properties than the components that comprise them. Of the many uses for co-crystals, some of the more popular uses extend into pharmaceutical and energetic materials research where active pharmaceutical ingredients, or APIs, are co-crystallized with coformers to improve bioavailability and solubility. Mechanochemistry has emerged as a key tool in the synthesis and engineering of co-crystals due to how quickly co-crystals can be generated when compared to growing crystals using slow evaporation. Among the several mechanochemical methods used for co-crystal production such as ball-milling and grinding, liquid-assisted sonication offers a quick and easy method for the formation of co-crystals with the added benefit of being able to be performed at the milligram scale which decreases the amount of material needed for these experiments. Powder x-ray diffraction, or PXRD, is how the formation of a co-crystal can be analyzed by comparing the powder patterns of each component and the mixture. If the mixture is unique to both components, then there exists the likelihood that a co-crystal had formed. The presence of a co-crystal cannot be confirmed using this method, but it can narrow down choices for growing single crystals which leads to a single crystal structure that will confirm a co-crystal.In this work, we are interested in forming co-crystals of photochromic ruthenium sulfoxide complexes that undergo a linkage isomerization from the S-bonded form to the O-bonded form when irradiated. Utilizing high-throughput liquid-assisted sonication, potential co-crystals are found which will lead to the ultimate goal of single crystals of the co-crystals for time resolved x-ray studies."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Developing High Throughput Screening Methods for Co-crystal Photoactivity"]}]}],"canonical_facts":{"dc:contributor":["Benedict, Jason","Chemistry"],"dc:creator":["Tysoe, Andrew"],"dc:date":["2019-04-04T20:32:37Z","2019","2019-01-16 16:54:47"],"dc:description":["M.A.","Co-crystals are a subclass of crystals that are comprised of two or more different molecular components. A major theme in co-crystal research is that co-crystals display different properties than the components that comprise them. Of the many uses for co-crystals, some of the more popular uses extend into pharmaceutical and energetic materials research where active pharmaceutical ingredients, or APIs, are co-crystallized with coformers to improve bioavailability and solubility. Mechanochemistry has emerged as a key tool in the synthesis and engineering of co-crystals due to how quickly co-crystals can be generated when compared to growing crystals using slow evaporation. Among the several mechanochemical methods used for co-crystal production such as ball-milling and grinding, liquid-assisted sonication offers a quick and easy method for the formation of co-crystals with the added benefit of being able to be performed at the milligram scale which decreases the amount of material needed for these experiments. Powder x-ray diffraction, or PXRD, is how the formation of a co-crystal can be analyzed by comparing the powder patterns of each component and the mixture. If the mixture is unique to both components, then there exists the likelihood that a co-crystal had formed. The presence of a co-crystal cannot be confirmed using this method, but it can narrow down choices for growing single crystals which leads to a single crystal structure that will confirm a co-crystal.In this work, we are interested in forming co-crystals of photochromic ruthenium sulfoxide complexes that undergo a linkage isomerization from the S-bonded form to the O-bonded form when irradiated. Utilizing high-throughput liquid-assisted sonication, potential co-crystals are found which will lead to the ultimate goal of single crystals of the co-crystals for time resolved x-ray studies."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/79412"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["physical chemistry"],"dc:title":["Developing High Throughput Screening Methods for Co-crystal Photoactivity"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:16Z"}