{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/79320"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/79320","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Deorphanizing Monocarboxylate Transporter 6: Evidence of Functional Roles in Lipid Metabolism and Drug Transport","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Jones, Robert"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Morris, Marilyn","Pharmaceutical Sciences"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-04-04T18:47:37Z","date_published":"2019-04-04T18:47:37Z","updated_at":"2026-07-27T19:05:14Z","subjects":["pharmaceutical sciences"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/79320","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Morris, Marilyn","Pharmaceutical Sciences"]},{"key":"dc:creator","label":"Author","values":["Jones, Robert"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-04-04T18:47:37Z","2019","2019-01-18 11:30:52"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["pharmaceutical sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/79320"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","Monocarboxylate transporters (MCTs) are members of the solute carrier 16 (SLC16) family of transporter proteins that are responsible for wide range of essential physiological processes. In total, there are fourteen isoforms that vary in their expression profiles, localization, and substrate/inhibitor specificity which allow for each individual isoform to have distinct endogenous functions. Specifically, MCTs 1-4 contribute to proton-dependent lactate/pyruvate shuttling between oxidative and glycolytic cells that influences the availability of cellular nutrients and maintains pH homeostasis. MCT8 and MCT10 transport thyroid hormone and aromatic amino acids respectively, which have a substantial impact on the cell growth and development. Because of their importance in these fundamental biological pathways, MCTs have a broad range of clinical utilities in disease as targets and biomarkers. Recently, it has become evident that other lesser studied members of this family (that previously had no known function, and thus termed “orphan” transporters), are implicated in diseases such as type II diabetes (MCT11) and cataract formation (MCT12). Another orphan MCT isoform, MCT6 (SLC16A5), has been investigated to characterize its substrate specificity and functional dependencies. That research, though limited, revealed that MCT6 transports a handful of organic anion xenobiotics including bumetanide, nateglinide, probenecid, and prostaglandin F2α. In addition, MCT6 exhibits pH and membrane potential-dependent transport, and is expressed in human intestine. Transcriptomic data published by independent labs show that MCT6 is markedly upregulated in mouse liver following fasting and administration of a fenofibrate-supplemented diet, suggesting it may play a role in lipid metabolic pathways. Based on this information, our hypothesis was that MCT6 functions as a mediator in lipid metabolism and plays a major role in organic anion drug transport.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Deorphanizing Monocarboxylate Transporter 6: Evidence of Functional Roles in Lipid Metabolism and Drug Transport"]}]}],"canonical_facts":{"dc:contributor":["Morris, Marilyn","Pharmaceutical Sciences"],"dc:creator":["Jones, Robert"],"dc:date":["2019-04-04T18:47:37Z","2019","2019-01-18 11:30:52"],"dc:description":["Ph.D.","Monocarboxylate transporters (MCTs) are members of the solute carrier 16 (SLC16) family of transporter proteins that are responsible for wide range of essential physiological processes. In total, there are fourteen isoforms that vary in their expression profiles, localization, and substrate/inhibitor specificity which allow for each individual isoform to have distinct endogenous functions. Specifically, MCTs 1-4 contribute to proton-dependent lactate/pyruvate shuttling between oxidative and glycolytic cells that influences the availability of cellular nutrients and maintains pH homeostasis. MCT8 and MCT10 transport thyroid hormone and aromatic amino acids respectively, which have a substantial impact on the cell growth and development. Because of their importance in these fundamental biological pathways, MCTs have a broad range of clinical utilities in disease as targets and biomarkers. Recently, it has become evident that other lesser studied members of this family (that previously had no known function, and thus termed “orphan” transporters), are implicated in diseases such as type II diabetes (MCT11) and cataract formation (MCT12). Another orphan MCT isoform, MCT6 (SLC16A5), has been investigated to characterize its substrate specificity and functional dependencies. That research, though limited, revealed that MCT6 transports a handful of organic anion xenobiotics including bumetanide, nateglinide, probenecid, and prostaglandin F2α. In addition, MCT6 exhibits pH and membrane potential-dependent transport, and is expressed in human intestine. Transcriptomic data published by independent labs show that MCT6 is markedly upregulated in mouse liver following fasting and administration of a fenofibrate-supplemented diet, suggesting it may play a role in lipid metabolic pathways. Based on this information, our hypothesis was that MCT6 functions as a mediator in lipid metabolism and plays a major role in organic anion drug transport.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/79320"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["pharmaceutical sciences"],"dc:title":["Deorphanizing Monocarboxylate Transporter 6: Evidence of Functional Roles in Lipid Metabolism and Drug Transport"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:14Z"}