{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/79303"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/79303","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Copper-Catalyzed Synthesis of Heterocyclic Rings via Alkene Difunctionalization","abstract":"Ph.D.","abstract_html":"Ph.D.","abstract_has_math":false,"creators":["Khoder, Zainab"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Chemler, Sherry","Chemistry"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-04-02T17:19:25Z","date_published":"2019-04-02T17:19:25Z","updated_at":"2026-07-27T19:05:14Z","subjects":["chemistry"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/79303","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Chemler, Sherry","Chemistry"]},{"key":"dc:creator","label":"Author","values":["Khoder, Zainab"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-04-02T17:19:25Z","2019","2018-11-19 12:40:20"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["chemistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/79303"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ph.D.","Alkene diamination is an important strategy in synthetic chemistry. It gives access to 1,2-vicinal diamines, and in the method disclosed in this chapter, 1,2-diamino-3-alcohols. These scaffolds are useful in many medicinally active compounds. Herein, we describe how earth abundant copper salts are applied in the synthesis of isoxazolidine rings using alkenes. These products can be converted to the 1,3-diamino alcohols. The isoxazolidine products were obtained in a very good diastereoselectivity. The mild reaction conditions enabled a wider amine scope including alkyl and arylamines, benzamides, sulfonamides and anilines. Carbamate-functionalized substrates were uniquely active for the first time in our copper chemistry."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Copper-Catalyzed Synthesis of Heterocyclic Rings via Alkene Difunctionalization"]}]}],"canonical_facts":{"dc:contributor":["Chemler, Sherry","Chemistry"],"dc:creator":["Khoder, Zainab"],"dc:date":["2019-04-02T17:19:25Z","2019","2018-11-19 12:40:20"],"dc:description":["Ph.D.","Alkene diamination is an important strategy in synthetic chemistry. It gives access to 1,2-vicinal diamines, and in the method disclosed in this chapter, 1,2-diamino-3-alcohols. These scaffolds are useful in many medicinally active compounds. Herein, we describe how earth abundant copper salts are applied in the synthesis of isoxazolidine rings using alkenes. These products can be converted to the 1,3-diamino alcohols. The isoxazolidine products were obtained in a very good diastereoselectivity. The mild reaction conditions enabled a wider amine scope including alkyl and arylamines, benzamides, sulfonamides and anilines. Carbamate-functionalized substrates were uniquely active for the first time in our copper chemistry."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/79303"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["chemistry"],"dc:title":["Copper-Catalyzed Synthesis of Heterocyclic Rings via Alkene Difunctionalization"],"dc:type":["Text","Dissertation"]},"updated_at":"2026-07-27T19:05:14Z"}