{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/78626"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/78626","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Loading and Releasing Ciprofloxacin in Photoactivatable Liposomes","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Ghosh, Sanjana"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Lovell, Jonathan","Biomedical Engineering"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-10-26T02:57:03Z","date_published":"2018-10-26T02:57:03Z","updated_at":"2026-07-27T19:05:14Z","subjects":["nanoscience","nanotechnology","medicine"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/78626","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Lovell, Jonathan","Biomedical Engineering"]},{"key":"dc:creator","label":"Author","values":["Ghosh, Sanjana"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2018-10-26T02:57:03Z","2018","2018-08-10 22:17:58"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["nanoscience","nanotechnology","medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/78626"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","We demonstrate that ciprofloxacin can be actively loaded into liposomes that contain small amounts of porphyrin-phospholipid (PoP). PoP renders the liposomes photoactivatable, so that the antibiotic is released from the carrier under red light irradiation. The liposome formulation was optimized for ciprofloxacin loading, storage stability, and rapid light-triggered drug release. Use of 2 molar % PoP liposomes allowed maximum active loading of Ciprofloxacin. Inclusion of 2 molar % of an unsaturated phospholipid further accelerated light-triggered drug release (more than 90% in less than 30 seconds). With or without laser treatment, ciprofloxacin PoP liposomes inhibited the growth of Bacillus subtilis in liquid media, apparently due to uptake of the liposomes by the bacteria. However, when liposomes were first separated from smaller molecules with centrifugal filtration, only the filtrate from laser-treated liposomes was bactericidal, demonstrating effective release of intact antibiotic. These results establish the feasibility of actively loading antibiotics into photoactivatable liposomes, which could create new possibilities for enhanced localized antibiotic therapy."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Loading and Releasing Ciprofloxacin in Photoactivatable Liposomes"]}]}],"canonical_facts":{"dc:contributor":["Lovell, Jonathan","Biomedical Engineering"],"dc:creator":["Ghosh, Sanjana"],"dc:date":["2018-10-26T02:57:03Z","2018","2018-08-10 22:17:58"],"dc:description":["M.S.","We demonstrate that ciprofloxacin can be actively loaded into liposomes that contain small amounts of porphyrin-phospholipid (PoP). PoP renders the liposomes photoactivatable, so that the antibiotic is released from the carrier under red light irradiation. The liposome formulation was optimized for ciprofloxacin loading, storage stability, and rapid light-triggered drug release. Use of 2 molar % PoP liposomes allowed maximum active loading of Ciprofloxacin. Inclusion of 2 molar % of an unsaturated phospholipid further accelerated light-triggered drug release (more than 90% in less than 30 seconds). With or without laser treatment, ciprofloxacin PoP liposomes inhibited the growth of Bacillus subtilis in liquid media, apparently due to uptake of the liposomes by the bacteria. However, when liposomes were first separated from smaller molecules with centrifugal filtration, only the filtrate from laser-treated liposomes was bactericidal, demonstrating effective release of intact antibiotic. These results establish the feasibility of actively loading antibiotics into photoactivatable liposomes, which could create new possibilities for enhanced localized antibiotic therapy."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/78626"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["nanoscience","nanotechnology","medicine"],"dc:title":["Loading and Releasing Ciprofloxacin in Photoactivatable Liposomes"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:14Z"}