{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/78516"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/78516","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Effects of the TAAR1 agonist RO5263397 on Ethanol-induced Behavioral Sensitization","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Wang, Kaixuan; 0000-0002-1374-7811"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Li, Jun-Xu","Neuroscience"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-10-26T02:54:41Z","date_published":"2018-10-26T02:54:41Z","updated_at":"2026-07-27T19:05:12Z","subjects":["neurosciences","pharmacology","behavioral sciences"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/78516","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Li, Jun-Xu","Neuroscience"]},{"key":"dc:creator","label":"Author","values":["Wang, Kaixuan; 0000-0002-1374-7811"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2018-10-26T02:54:41Z","2018","2018-07-13 12:39:12"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["neurosciences","pharmacology","behavioral sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/78516"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","Trace amine-associate receptor 1 (TAAR1), was recognized as a promising target for treating drug addictions and multiple neuropsychiatric disorders, due to its function in modulating dopaminergic systems in the central nervous system (CNS). Previous research has studied the significant effects of selective TAAR1 agonist RO5263397 in addictive-like behaviors of different drugs of abuse. However, little is known about the role of TAAR1 in alcohol addiction. In addition, the connection with alcohol-induced addictive-like behaviors remains unknown. Therefore, this thesis sought to study the effect of TAAR1 agonist RO5263397 in ethanol-induced locomotor sensitization. Firstly, we wanted to confirm that daily ethanol administration would reduce locomotor sensitization. We observed ethanol-induced sensitization in wildtype (WT) mice that were treated with ethanol daily (for 10 consecutive days). Next, we investigated the effect of RO5263397 in the expression of sensitization. We found that pre-treatment of RO5263397 attenuated the expression of ethanol-induced locomotor sensitization in WT mice. Interestingly, there were significant sex differences in both induction and expression phases of ethanol-induced behavioral sensitization. Finally, RO5263397 was not able to alter the augmented locomotor activities in the expression of sensitization in taar1 KO mice, confirming the selectivity of RO5263397 to TAAR1. Collectively, this thesis introduces a novel perspective of the role of TAAR1 in alcohol abuse-related behaviors, and supports the idea of TAAR1 as a potential therapeutic target for alcohol addiction."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Effects of the TAAR1 agonist RO5263397 on Ethanol-induced Behavioral Sensitization"]}]}],"canonical_facts":{"dc:contributor":["Li, Jun-Xu","Neuroscience"],"dc:creator":["Wang, Kaixuan; 0000-0002-1374-7811"],"dc:date":["2018-10-26T02:54:41Z","2018","2018-07-13 12:39:12"],"dc:description":["M.S.","Trace amine-associate receptor 1 (TAAR1), was recognized as a promising target for treating drug addictions and multiple neuropsychiatric disorders, due to its function in modulating dopaminergic systems in the central nervous system (CNS). Previous research has studied the significant effects of selective TAAR1 agonist RO5263397 in addictive-like behaviors of different drugs of abuse. However, little is known about the role of TAAR1 in alcohol addiction. In addition, the connection with alcohol-induced addictive-like behaviors remains unknown. Therefore, this thesis sought to study the effect of TAAR1 agonist RO5263397 in ethanol-induced locomotor sensitization. Firstly, we wanted to confirm that daily ethanol administration would reduce locomotor sensitization. We observed ethanol-induced sensitization in wildtype (WT) mice that were treated with ethanol daily (for 10 consecutive days). Next, we investigated the effect of RO5263397 in the expression of sensitization. We found that pre-treatment of RO5263397 attenuated the expression of ethanol-induced locomotor sensitization in WT mice. Interestingly, there were significant sex differences in both induction and expression phases of ethanol-induced behavioral sensitization. Finally, RO5263397 was not able to alter the augmented locomotor activities in the expression of sensitization in taar1 KO mice, confirming the selectivity of RO5263397 to TAAR1. Collectively, this thesis introduces a novel perspective of the role of TAAR1 in alcohol abuse-related behaviors, and supports the idea of TAAR1 as a potential therapeutic target for alcohol addiction."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/78516"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["neurosciences","pharmacology","behavioral sciences"],"dc:title":["Effects of the TAAR1 agonist RO5263397 on Ethanol-induced Behavioral Sensitization"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:12Z"}