{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/78506"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/78506","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Effects of Trace Amine-Associated Receptor 1 Partial Agonist RO5263397 on Morphine-Related Behaviors","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Johnson, Bernard; 0000-0002-3152-737X"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Li, Jun-Xu","Pharmacology and Toxicology"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-10-26T02:54:31Z","date_published":"2018-10-26T02:54:31Z","updated_at":"2026-07-27T19:05:09Z","subjects":["pharmacology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/78506","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Li, Jun-Xu","Pharmacology and Toxicology"]},{"key":"dc:creator","label":"Author","values":["Johnson, Bernard; 0000-0002-3152-737X"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2018-10-26T02:54:31Z","2018","2018-08-06 20:13:21"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["pharmacology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/78506"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","A novel G-protein coupled receptor, trace amine-associated receptor 1 (TAAR1), has been identified as an important modulator of the dopaminergic system. As such, TAAR1 has been shown to have a critical role in regulating the rewarding properties of drugs of abuse. Previous research has shown pharmacological activation of TAAR1 decreased the abuse-related behavioral effects of psychostimulants. However, the role of TAAR1 in opioid-related behaviors is still elusive. Although opioid and psychostimulant addiction are behaviorally and neurobiological distinct, they share the ability to increase dopamine levels in the mesocorticolimbic dopamine system. TAAR1 therefore has the potential as a novel therapeutic target to treat opioid use disorder. This thesis investigated the effects of a selective TAAR1 partial agonist RO5263397 on morphine-related behaviors. We found that RO5263397 attenuated morphine-intake in morphine self-administration model and decreased the breakpoint under progressive-ratio schedule of responding. RO5263397 did not affect morphine-induced conditioned place preference; neither did it have a significant effect on naltrexone-induced conditioned place aversion or naltrexone-precipitated jumping behavior in morphine-dependent mice. In addition, RO5263397 had no effect on the analgesic effect of morphine in acute pain model. Taken together, these results suggest TAAR1 agonist RO5263397 selectively affects reinforcing properties of morphine."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Effects of Trace Amine-Associated Receptor 1 Partial Agonist RO5263397 on Morphine-Related Behaviors"]}]}],"canonical_facts":{"dc:contributor":["Li, Jun-Xu","Pharmacology and Toxicology"],"dc:creator":["Johnson, Bernard; 0000-0002-3152-737X"],"dc:date":["2018-10-26T02:54:31Z","2018","2018-08-06 20:13:21"],"dc:description":["M.S.","A novel G-protein coupled receptor, trace amine-associated receptor 1 (TAAR1), has been identified as an important modulator of the dopaminergic system. As such, TAAR1 has been shown to have a critical role in regulating the rewarding properties of drugs of abuse. Previous research has shown pharmacological activation of TAAR1 decreased the abuse-related behavioral effects of psychostimulants. However, the role of TAAR1 in opioid-related behaviors is still elusive. Although opioid and psychostimulant addiction are behaviorally and neurobiological distinct, they share the ability to increase dopamine levels in the mesocorticolimbic dopamine system. TAAR1 therefore has the potential as a novel therapeutic target to treat opioid use disorder. This thesis investigated the effects of a selective TAAR1 partial agonist RO5263397 on morphine-related behaviors. We found that RO5263397 attenuated morphine-intake in morphine self-administration model and decreased the breakpoint under progressive-ratio schedule of responding. RO5263397 did not affect morphine-induced conditioned place preference; neither did it have a significant effect on naltrexone-induced conditioned place aversion or naltrexone-precipitated jumping behavior in morphine-dependent mice. In addition, RO5263397 had no effect on the analgesic effect of morphine in acute pain model. Taken together, these results suggest TAAR1 agonist RO5263397 selectively affects reinforcing properties of morphine."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/78506"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["pharmacology"],"dc:title":["Effects of Trace Amine-Associated Receptor 1 Partial Agonist RO5263397 on Morphine-Related Behaviors"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:09Z"}