{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/78413"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/78413","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"The Effect of ChemicalX in Reducing Cisplatin-Induced Toxicities, Particularly Nephrotoxicity","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Zheng, Nina; 0000-0002-6496-6715"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Ren, Xuefeng","Pharmacology and Toxicology"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-10-24T20:48:43Z","date_published":"2018-10-24T20:48:43Z","updated_at":"2026-07-27T19:05:09Z","subjects":["toxicology","pharmacology","oncology"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/78413","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Ren, Xuefeng","Pharmacology and Toxicology"]},{"key":"dc:creator","label":"Author","values":["Zheng, Nina; 0000-0002-6496-6715"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2018-10-24T20:48:43Z","2018","2018-08-06 14:32:52"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["toxicology","pharmacology","oncology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/78413"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","Cisplatin is a platinum-based chemotherapeutic drug widely used in the treatment of various cancers such as testicular, ovarian, lung, bladder, and cervical cancers. However, its dose is limited by severe side effects including gastrointestinal toxicity, neurotoxicity, myelosuppression, ototoxicity, and most commonly nephrotoxicity. GMDTC is a newly synthesized chelator that has been shown to be of low toxicity and capable of chelating various heavy metals. The objectives of this project are to determine whether GMDTC can react with cisplatin to reduce cisplatin-induced nephrotoxicity in vitro using HK2 and LLC-PK1 cells and in vivo using a 4T1 breast tumor model in BALB/c and a MDA-MB-231 breast tumor model in nude mice. In vivo, the ability of GMDTC to reduce other cisplatin-induced toxicities will also be examined. This project will also assess the effect of GMDTC on the antitumor efficacy of cisplatin in BALB/c mice. The molecular mechanisms by which GMDTC reduces cisplatin-induced nephrotoxicity will also be assessed."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["The Effect of ChemicalX in Reducing Cisplatin-Induced Toxicities, Particularly Nephrotoxicity"]}]}],"canonical_facts":{"dc:contributor":["Ren, Xuefeng","Pharmacology and Toxicology"],"dc:creator":["Zheng, Nina; 0000-0002-6496-6715"],"dc:date":["2018-10-24T20:48:43Z","2018","2018-08-06 14:32:52"],"dc:description":["M.S.","Cisplatin is a platinum-based chemotherapeutic drug widely used in the treatment of various cancers such as testicular, ovarian, lung, bladder, and cervical cancers. However, its dose is limited by severe side effects including gastrointestinal toxicity, neurotoxicity, myelosuppression, ototoxicity, and most commonly nephrotoxicity. GMDTC is a newly synthesized chelator that has been shown to be of low toxicity and capable of chelating various heavy metals. The objectives of this project are to determine whether GMDTC can react with cisplatin to reduce cisplatin-induced nephrotoxicity in vitro using HK2 and LLC-PK1 cells and in vivo using a 4T1 breast tumor model in BALB/c and a MDA-MB-231 breast tumor model in nude mice. In vivo, the ability of GMDTC to reduce other cisplatin-induced toxicities will also be examined. This project will also assess the effect of GMDTC on the antitumor efficacy of cisplatin in BALB/c mice. The molecular mechanisms by which GMDTC reduces cisplatin-induced nephrotoxicity will also be assessed."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/78413"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["toxicology","pharmacology","oncology"],"dc:title":["The Effect of ChemicalX in Reducing Cisplatin-Induced Toxicities, Particularly Nephrotoxicity"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:09Z"}