{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/78407"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/78407","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"Lyotropic Liquid Crystal Gels of Poloxamer Block Copolymers for Transdermal Delivery Applications","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Sui, Yiyan; 0000-0002-1957-0025"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Alexandridis, Paschalis","Chemical and Biological Engineering"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-10-24T20:15:06Z","date_published":"2018-10-24T20:15:06Z","updated_at":"2026-07-27T19:05:09Z","subjects":["chemical engineering"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/78407","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Alexandridis, Paschalis","Chemical and Biological Engineering"]},{"key":"dc:creator","label":"Author","values":["Sui, Yiyan; 0000-0002-1957-0025"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2018-10-24T20:15:06Z","2018","2018-08-01 18:57:21"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["chemical engineering"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/78407"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","Transdermal drug delivery systems (TDDS) which combine the advantages of conventional drug delivery routes such as portability and fewer side effects, constitute a popular research direction in drug administration. Lyotropic liquid crystals (LLCs) formed by amphiphilic molecules and solvents exhibit good penetration that can help drugs distribute into the skin. In this study, LLC gels self-assembled by pharmaceutically approved poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) block copolymers (commercially available as Poloxamers or Pluronics) have been considered as a potential drug carrier system which can be applied intransdermal administration. The aim of this study is to produce LLC drug carriers that not only have higher drug loading, but also use the least amount of surfactants and cosolvents. Factors that influence the phase behavior of Pluronic systems such as the cosolvent and temperature are discussed. The results indicate that hexagonal LLC forms at Pluronic concentration between 40% and 70%, while micellar cubic LLC between 30% and 40%. Polar cosolvents ethanol, isopropanol and glycerol have different effect on the interfacial curvature because of the location preference in the different segregated domains of PEO-PPO-PEO block copolymers. A rise of temperature canresult in a phase transition to the direction of decreased interfacial curvature. Suitable compositions with homogenous and thermodynamically stable LLCs have been selected for future research.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Lyotropic Liquid Crystal Gels of Poloxamer Block Copolymers for Transdermal Delivery Applications"]}]}],"canonical_facts":{"dc:contributor":["Alexandridis, Paschalis","Chemical and Biological Engineering"],"dc:creator":["Sui, Yiyan; 0000-0002-1957-0025"],"dc:date":["2018-10-24T20:15:06Z","2018","2018-08-01 18:57:21"],"dc:description":["M.S.","Transdermal drug delivery systems (TDDS) which combine the advantages of conventional drug delivery routes such as portability and fewer side effects, constitute a popular research direction in drug administration. Lyotropic liquid crystals (LLCs) formed by amphiphilic molecules and solvents exhibit good penetration that can help drugs distribute into the skin. In this study, LLC gels self-assembled by pharmaceutically approved poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) block copolymers (commercially available as Poloxamers or Pluronics) have been considered as a potential drug carrier system which can be applied intransdermal administration. The aim of this study is to produce LLC drug carriers that not only have higher drug loading, but also use the least amount of surfactants and cosolvents. Factors that influence the phase behavior of Pluronic systems such as the cosolvent and temperature are discussed. The results indicate that hexagonal LLC forms at Pluronic concentration between 40% and 70%, while micellar cubic LLC between 30% and 40%. Polar cosolvents ethanol, isopropanol and glycerol have different effect on the interfacial curvature because of the location preference in the different segregated domains of PEO-PPO-PEO block copolymers. A rise of temperature canresult in a phase transition to the direction of decreased interfacial curvature. Suitable compositions with homogenous and thermodynamically stable LLCs have been selected for future research.","**To request an accessible version of the file(s) associated with this item, contact library@buffalo.edu. Please include the item's persistent URL [http://hdl.handle.net/. . .] in your request.**"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/78407"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["chemical engineering"],"dc:title":["Lyotropic Liquid Crystal Gels of Poloxamer Block Copolymers for Transdermal Delivery Applications"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:09Z"}