Physicomechanical Response of Ionic Polyurethanes on Endothelial Cells

Segmental polyurethanes (PUs) are well-characterized elastomeric biomaterials that are used in vascular graft applications. PU properties can be engineered by tuning their segmental composition and by regulating inter-segmental interactions. We aim to use ionic PUs as representative vascular graft material to analyze the response of human endothelial cells and correlate it to cell-matrix interactions. We propose to use polycaprolactone-based ionic PU and design a composite (blend) of cationic and anionic PUs to modulate the physicomechanical properties. PUs are designed with two different diisocyanates, hexamethylene diisocyanate (HDI), which has a linear structure and isophorone diisocyanate (IPDI), with a non-linear structure. By utilizing the inter-segmental interaction along with ionic interactions, the relaxation of PU chains can lead to well-defined physicomechanical responses, specifically, viscoelasticity and surface property. Using this system, we aim to underline the interaction between endothelial cells and PUs. The cellular response of HUVECs on the designed PUs will provide understanding of cell-matrix interactions, which can be employed to develop cellularized graft for vascular applications.

Grantor dc:publisher

State University of New York at Buffalo

Year dc:date.issued

2018

Author dc:creator

• Ansari, Farheen

Contributors dc:contributor

• Sarkar, Debanjan
• Biomedical Engineering

• biomedical engineering

Statement dc:rights

• Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.
• Copyright retained by author.

Language dc:language

eng

Handle dc:identifier

http://hdl.handle.net/10477/77937

OAI record oai:identifier

https://ubir.buffalo.edu/oai/request?verb=GetRecord&metadataPrefix=qdc&identifier=oai%3Aubir.buffalo.edu%3A10477%2F77937