Mapping cerebral blood flow with speckle contrast optical spectroscopy

Cerebral blood flow (CBF) is a critical component of cerebral hemodynamics, yet the existing optical neuroimaging modalities to measure CBF do not have sufficient signal-to-noise ratio. Speckle contrast optical spectroscopy (SCOS) has been previously considered as an alternative approach to use near-infrared light to measure CBF non-invasively in humans. Several advancements in use of SCOS for CBF measurement are presented here. A data processing pipeline considering various noise sources and a pulsed laser setup were developed to account for the low photon flux at the source detector separations necessary in human CBF measurement. A camera characterization pipeline optimized for SCOS was developed to expand the range of cameras available. By choosing scalable source and detector systems, a high density, multi-channel SCOS system was developed, allowing for mapping of CBF changes during cognitive task induced cerebral activity. With these three advancements, non-invasively monitoring CBF changes in humans with high spatial and temporal resolution becomes possible.

Author dc:creator

• Kim, Byungchan

Advisors dc:contributor.advisor

• Boas, David A.
• Cheng, Xiaojun

• Biomedical engineering
• Optics
• Neurosciences

Statement dc:rights

• Attribution 4.0 International

Licence dc:rights.uri

• http://creativecommons.org/licenses/by/4.0/

Language dc:language.iso

en_US

Handle dc:identifier.uri

https://hdl.handle.net/2144/52143

OAI identifier oai:identifier

oai:open.bu.edu:2144/52143