Association between venoarterial extracorporeal membrane oxygenation start time and patient outcomes

Introduction: Extracorporeal membrane oxygenation (ECMO) is a complex tool used in times of cardio and pulmonary failures. It began as a tool used in neonates and gradually evolved to adult use in 2003 and increased in popularity during the time of the H1N1 influenza. As this procedure is risky, it is important to assure all factors are optimized to ensure successful patient outcomes. The time of day a patient is placed on ECMO may play a significance in determining their survival after ECMO. Methods: The study was performed as a single-center, retrospective chart review and database analysis of prospectively collected data from February 7th, 2009 until December 31st, 2021. Data was analyzed using Excel and R studio and logistic regressions and odds ratios were calculated assessing time of day a patient was placed on ECMO to survival to ECMO decannulation, survival to discharge, and survival to one year. Results: There was no statistically significant correlation for time of day and survival outcomes of ECMO except for survival to discharge. Survival to discharge had a positive odds ratio associated with day hours with a statistically significant p value. Discussion: There is no immediate explanation why survival to discharge had a statistically significant correlation with time of day and survival to ECMO decannulation did not. It is possible that the study needs to be repeated with a greater sample size to produce statistically significant results. It is possible that there is a correlation with time of day and ECMO outcomes but the sample size is not large enough to convey that.

Author dc:creator

• Alsheraa, Zeinab

Advisor dc:contributor.advisor

• McKnight, C. James

• Medicine
• ECMO
• Start times
• Statistics
• Time of day
• Venoarterial extracorporeal membrane oxygenation

Language dc:language.iso

en_US

Handle dc:identifier.uri

https://hdl.handle.net/2144/49446

OAI identifier oai:identifier

oai:open.bu.edu:2144/49446