{"id":{"repo_id":"bu","oai_identifier":"oai:open.bu.edu:2144/24589"},"canonical_url":"https://search.dev.ndltd.org/etd/bu/oai:open.bu.edu:2144/24589","repository":{"repo_id":"bu","name":"Boston University","base_url":"https://open.bu.edu/oai/request"},"display":{"title":"Metabolism of testosterone by tissue enzymes","abstract":"From a series of in vitro incubations with human skin the existence of an enzyme system which metabolizes testosterone to [triangle]^4-androstene-3, 17-dione and \"polar compounds\" has been established. Several enzyme systems are felt to be active in testosterone breakdown by human skin; some of these from \"polar compounds\", one of them forms [triangle]^4-androstene-3,17-dione, while others form additional unknown ketonic compounds. These skin enzymes were found to vary quantitatively among different subjects. [TRUNCATED]","abstract_html":"From a series of in vitro incubations with human skin the existence of an enzyme system which metabolizes testosterone to [triangle]^4-androstene-3, 17-dione and "polar compounds" has been established. Several enzyme systems are felt to be active in testosterone breakdown by human skin; some of these from "polar compounds", one of them forms [triangle]^4-androstene-3,17-dione, while others form additional unknown ketonic compounds. These skin enzymes were found to vary quantitatively among different subjects. [TRUNCATED]","abstract_has_math":false,"creators":["Simpson, Norma J."],"institution":"Boston University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1957,"date_issued":"1957","date_published":"1957","updated_at":"2026-07-24T01:24:17Z","subjects":[],"languages":["en_US"],"rights":["Based on investigation of the BU Libraries' staff, this work is free of known copyright restrictions."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["b14753273"],"render_values":[{"text":"b14753273","href":null,"code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/2144/24589","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Simpson, Norma J."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-11-01T13:12:54Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2017-11-01T13:12:54Z"]},{"key":"dc:date.issued","label":"Date","values":["1957"]},{"key":"dc:publisher","label":"Institution","values":["Boston University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis/Dissertation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]},{"key":"dc:rights","label":"Dc Rights","values":["Based on investigation of the BU Libraries' staff, this work is free of known copyright restrictions."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["b14753273"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/2144/24589"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Thesis (M.A.)--Boston University"]},{"key":"dc:description.abstract","label":"Abstract","values":["From a series of in vitro incubations with human skin the existence of an enzyme system which metabolizes testosterone to [triangle]^4-androstene-3, 17-dione and \"polar compounds\" has been established. Several enzyme systems are felt to be active in testosterone breakdown by human skin; some of these from \"polar compounds\", one of them forms [triangle]^4-androstene-3,17-dione, while others form additional unknown ketonic compounds. These skin enzymes were found to vary quantitatively among different subjects. [TRUNCATED]"]},{"key":"dc:title","label":"Title","values":["Metabolism of testosterone by tissue enzymes"]}]}],"canonical_facts":{"dc:creator":["Simpson, Norma J."],"dc:date.accessioned":["2017-11-01T13:12:54Z"],"dc:date.available":["2017-11-01T13:12:54Z"],"dc:date.issued":["1957"],"dc:description":["Thesis (M.A.)--Boston University"],"dc:description.abstract":["From a series of in vitro incubations with human skin the existence of an enzyme system which metabolizes testosterone to [triangle]^4-androstene-3, 17-dione and \"polar compounds\" has been established. Several enzyme systems are felt to be active in testosterone breakdown by human skin; some of these from \"polar compounds\", one of them forms [triangle]^4-androstene-3,17-dione, while others form additional unknown ketonic compounds. These skin enzymes were found to vary quantitatively among different subjects. [TRUNCATED]"],"dc:identifier.other":["b14753273"],"dc:identifier.uri":["https://hdl.handle.net/2144/24589"],"dc:language.iso":["en_US"],"dc:publisher":["Boston University"],"dc:rights":["Based on investigation of the BU Libraries' staff, this work is free of known copyright restrictions."],"dc:title":["Metabolism of testosterone by tissue enzymes"],"dc:type":["Thesis/Dissertation"]},"updated_at":"2026-07-24T01:24:17Z"}