{"id":{"repo_id":"brock","oai_identifier":"oai:brocku.scholaris.ca:10464/4285"},"canonical_url":"https://search.dev.ndltd.org/etd/brock/oai:brocku.scholaris.ca:10464/4285","repository":{"repo_id":"brock","name":"Brock University","base_url":"https://brocku.scholaris.ca/server/oai/request"},"display":{"title":"Chemoenzymatic Synthesis of ent-Neopinone","abstract":"The present thesis describes the chemoenzymatic synthesis of ent-neopinone. The total synthesis of neopinone was accomplished in 14 steps from B-bromoethylbenzene. The synthesis began with a microbial oxidation of bromobenzene by Escherichia coli JM109(pDTG601) and features a Heck reaction, aldol condensation and a 1,6-conjugate addition.","abstract_html":"The present thesis describes the chemoenzymatic synthesis of ent-neopinone. The total synthesis of neopinone was accomplished in 14 steps from B-bromoethylbenzene. The synthesis began with a microbial oxidation of bromobenzene by Escherichia coli JM109(pDTG601) and features a Heck reaction, aldol condensation and a 1,6-conjugate addition.","abstract_has_math":false,"creators":["Piercy, T. Graeme"],"institution":"Brock University","degree_name":"M.Sc. Chemistry","degree_level":"Masters","degree_discipline":"Faculty of Mathematics and Science","degree_department":"Department of Chemistry","school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-04-11","date_published":"2013-04-11","updated_at":"2026-07-24T01:22:56Z","subjects":["Neopinone","Chemoenzymatic synthesis"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10464/4285","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.department","label":"Department","values":["Department of Chemistry"]},{"key":"dc:creator","label":"Author","values":["Piercy, T. Graeme"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2013-04-11T19:14:45Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2013-04-11T19:14:45Z"]},{"key":"dc:date.issued","label":"Date","values":["2013-04-11"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Faculty of Mathematics and Science"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.Sc. Chemistry"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Brock University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Neopinone","Chemoenzymatic synthesis"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10464/4285"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The present thesis describes the chemoenzymatic synthesis of ent-neopinone. The total synthesis of neopinone was accomplished in 14 steps from B-bromoethylbenzene. The synthesis began with a microbial oxidation of bromobenzene by Escherichia coli JM109(pDTG601) and features a Heck reaction, aldol condensation and a 1,6-conjugate addition."]},{"key":"dc:title","label":"Title","values":["Chemoenzymatic Synthesis of ent-Neopinone"]}]}],"canonical_facts":{"dc:contributor.department":["Department of Chemistry"],"dc:creator":["Piercy, T. Graeme"],"dc:date.accessioned":["2013-04-11T19:14:45Z"],"dc:date.available":["2013-04-11T19:14:45Z"],"dc:date.issued":["2013-04-11"],"dc:description.abstract":["The present thesis describes the chemoenzymatic synthesis of ent-neopinone. The total synthesis of neopinone was accomplished in 14 steps from B-bromoethylbenzene. The synthesis began with a microbial oxidation of bromobenzene by Escherichia coli JM109(pDTG601) and features a Heck reaction, aldol condensation and a 1,6-conjugate addition."],"dc:identifier.uri":["http://hdl.handle.net/10464/4285"],"dc:subject":["Neopinone","Chemoenzymatic synthesis"],"dc:title":["Chemoenzymatic Synthesis of ent-Neopinone"],"dc:type":["Electronic Thesis or Dissertation"],"thesis:degree_discipline":["Faculty of Mathematics and Science"],"thesis:degree_level":["Masters"],"thesis:degree_name":["M.Sc. Chemistry"],"thesis:institution_name":["Brock University"]},"updated_at":"2026-07-24T01:22:56Z"}