Abstract
dc:description.abstractFormulations of a general bactericidal agent, chlorhexidine, mixed with a phospholipid at different concentrations are investigated using ^H NMR spectroscopy on a chain-deuterated lipid analog. Lipid-chlorhexidine formulation is known to release the drug into an aqueous medium slowly, maintaining a comparable concentration of the drug for up to four times longer than a direct aqueous solution. The NMR data does not support the proposed liposomal entrapment of chlorhexidine in lipid compartments. Complex thermal history of the lipid-chlorhexidine preparations is investigated in detail. In preparation for a counterpart measurement, using ^H NMR of deuterated chlorhexidine mixed with protonated lipid, the synthesis of a deuterated analog of chlorhexidine is performed.
Degree
thesis:*- Name thesis:degree_name
- M.Sc. Physics
- Level thesis:degree_level
- Masters
- Discipline thesis:degree_discipline
- Faculty of Mathematics and Science
- Department dc:contributor.department
- Department of Physics
- Grantor
- Brock University
- Year dc:date.issued
- 2007
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Sadeghi, Sara.
Subjects
dc:subject × 2Rights
- Language dc:language.iso
- eng
Identifiers
dc:identifier.*- Handle dc:identifier.uri
- http://hdl.handle.net/10464/1554
- OAI identifier oai:identifier
- oai:brocku.scholaris.ca:10464/1554