Approaches towards C-10-hydroxylated analogues of narciclasine

Discussed in this thesis is the synthesis of a C10-benzyloxy unnatural derivative of narciclasine. The described approach involves the use of homochiral cyclohexadiene diols, products of the biocatalytic transformation of aromatic compounds, as precursors to ring C, and of highly oxygenated aromatic molecules to construct ring A. The document also reports a detailed account of the protocols studied for the intramolecular formation of ring B. Experimental data and spectral data are provided for the novel compounds.

Name thesis:degree_name

Ph.D. Chemistry

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Faculty of Mathematics and Science

Department dc:contributor.department

Department of Chemistry

Grantor

Brock University

Year dc:date.issued

2020

Author dc:creator

• Ticli, Vincenzo

• narciclasine amaryllidaceae biocatalysis total synthesis

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/10464/14970

OAI identifier oai:identifier

oai:brocku.scholaris.ca:10464/14970