Adesão ao tratamento farmacológico no pós-transplante de células-tronco hematopoéticas
type: CreativeWork
description: Introduction: Post-hematopoietic stem cell transplantation is a period in which adherence to pharmacological treatment is crucial to prevent complications such as graft-versus-host disease and graft failure. Therefore, the following research questions were formulated: What is the degree of adherence to pharmacological treatment in post-HSCT? What are the determining factors of adherence to pharmacological treatment in post-HSCT patients? What are the strategies to support adherence to pharmacological treatment used by post-HSCT patients? Objective: To investigate adherence to pharmacological treatment in post-hematopoietic stem cell transplant patients. Method: This is a cross-sectional study carried out between January and October 2024 in a reference hospital for hematopoietic stem cell transplantation in the state of Rio Grande do Norte. The population consisted of patients undergoing oral pharmacotherapy after stem cell grafting, treated at the Day Hospital. A questionnaire covering sociodemographic and clinical data, the Treatment Adherence Measurement Instrument, and questions about facilitating factors, challenges, interventions, and technologies to support adherence were used. Pearson's chi-square test and Student's t-test were used. Variables with p≤0.20 in the univariate analysis were included in the multiple logistic regression model. The magnitude of the association was calculated by the Prevalence Ratio. The significance level was 5% and the Confidence Interval was 95%. The project was approved by the Research Ethics Committee of the Federal University of Rio Grande do Norte, under opinion 6,599,477 and CAAE: 76470723.9.0000.5537. Results: The sample consisted of 99 participants, with a predominance of females (56.6%) and a mean age of 44.7 years. The most common diagnosis was acute myeloid leukemia (35.4%). Autologous transplantation was the most frequent type (52.5%) and systemic arterial hypertension was the most prevalent comorbidity (13.1%). 72.7% o…
abstract: Introduction: Post-hematopoietic stem cell transplantation is a period in which adherence to pharmacological treatment is crucial to prevent complications such as graft-versus-host disease and graft failure. Therefore, the following research questions were formulated: What is the degree of adherence to pharmacological treatment in post-HSCT? What are the determining factors of adherence to pharmacological treatment in post-HSCT patients? What are the strategies to support adherence to pharmacological treatment used by post-HSCT patients? Objective: To investigate adherence to pharmacological treatment in post-hematopoietic stem cell transplant patients. Method: This is a cross-sectional study carried out between January and October 2024 in a reference hospital for hematopoietic stem cell transplantation in the state of Rio Grande do Norte. The population consisted of patients undergoing oral pharmacotherapy after stem cell grafting, treated at the Day Hospital. A questionnaire covering sociodemographic and clinical data, the Treatment Adherence Measurement Instrument, and questions about facilitating factors, challenges, interventions, and technologies to support adherence were used. Pearson's chi-square test and Student's t-test were used. Variables with p≤0.20 in the univariate analysis were included in the multiple logistic regression model. The magnitude of the association was calculated by the Prevalence Ratio. The significance level was 5% and the Confidence Interval was 95%. The project was approved by the Research Ethics Committee of the Federal University of Rio Grande do Norte, under opinion 6,599,477 and CAAE: 76470723.9.0000.5537. Results: The sample consisted of 99 participants, with a predominance of females (56.6%) and a mean age of 44.7 years. The most common diagnosis was acute myeloid leukemia (35.4%). Autologous transplantation was the most frequent type (52.5%) and systemic arterial hypertension was the most prevalent comorbidity (13.1%). 72.7% o…
author: Souza, Larissa Beatriz Francisca de
language: pt_BR
keywords: Adesão à medicação, Transplante de células-tronco hematopoéticas, Enfermagem oncológica
date published: 2025-01-23
date modified: 2026-07-24T01:20:51Z
provider: Brazil UFRN
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Universidade Federal do Rio Grande do Norte