Avaliação da atividade antifúngica de fitoconstituintes contra candida albicans

Opportunistic infections are one of the major problems in immunocompromised patients, due to the high tendency by the patients to develop such infections. Amongst the large quantity of microorganisms, which might b e infecting patients with immunologic disorders, Candida albicans is the most reported agent causing fungal infections in humans. This fungus is an opportunistic pathogen, which has been found in the human body as a commensal organism, it may become pathog enic as a result of patient’s immunological responses or due to yeast’s virulence. In addition, microorganism’s resistance to the therapeutic agents is considerably increasing, so that, the necessity to develop new drugs with antifungal potential is also r ising, for example phytochemicals and other products from the environment. Therefore, the goal of this project was to analyse the antifungal activity of the phytochemical components citral and geraniol on strains of Candida albicans . The tests rea lised whe re: the phytochemical’s effect on the kinetic of the C. albicans growth and the activity of the composts on its micromorphology. Regarding to the kinetics of the fungal growth, a fungicide activity (reduction ≥ 3 log 10 UFC/mL from the initial inoculum) wa s observed utilizing citral on C. albicans ATCC 76485 and LM 70 strains, from 4 hours in a concentration of 64 μg/mL. On the other hand, utilizing geraniol, the fungicide effect on the strain ATCC76485 was observed from 2 hours, in a concentration of 32 μg /mL. To the LM 70 strain, fungicide effects appeared from 4 hours using the same concentration. The phytochemicals have shown reduction in the production of pseudohyphae and chlamydospores, which are factors involved in the pathogenic process of C. albican s . Regarding the results obtained, it can be conclude that citral and geraniol have presented considerable antifungal activity upon strains of C. albicans, highlighting the necessity of posterior studies about toxicity, mechanisms of action and in vivo tes ts, among others, in order to evaluate the possibility of developing drugs with security and efficacy

Grantor

UFPB

Year dc:date.issued

2015

Author dc:creator

• Bezerra, André Parente de Brito

• Candida Albicans
• Atividade Antifúngica
• Fitoconstituintes

Language dc:language.iso

pt

Repository record dc:identifier.uri

https://repositorio.ufpb.br/jspui/handle/123456789/926

OAI identifier oai:identifier

oai:repositorio.ufpb.br:123456789/926