{"id":{"repo_id":"brazil-ufpb","oai_identifier":"oai:repositorio.ufpb.br:123456789/602"},"canonical_url":"https://search.dev.ndltd.org/etd/brazil-ufpb/oai:repositorio.ufpb.br:123456789/602","repository":{"repo_id":"brazil-ufpb","name":"Brazil UFPB","base_url":"https://repositorio.ufpb.br/oai/request"},"display":{"title":"Cissampelos sympodialis EICHL. (Menispermaceae): avaliação das atividades antimotilidade e antidiarreica in vivo.","abstract":"Cissampelos sympodialis (Menispermaceae), known as \"Milona\" have a special verified medicinal use for the treatment of diarrhea and respiratory tract diseases. This species is rich in alkaloids , secondary metabolites that add the most diverse pharmacolo gical activities , among alkaloids isolated from C. sympodialis out to warifteíne and metilwarifteíne . This study aims to evaluate the antimotility and antidiarrheal activity of the crude ethanolic extract obtained from aerial parts of C. sympodialis (EtOH E - Cs ), by means of models of gastric emptying , intestinal normal transit and castor oil - induced diarrhea. The first two models evaluated the antimotility activity whi le the model of castor oil - induced diarrhea was used to evaluate the antidiarrheal activit y by means of the latter was investigated the possible mechanism of action of antidiarrheal activity of the species under study. The results indicated that the EtOHE - Cs not shown antimotility activity but showed antidiarrheal activity (at the dose of 500 m g/kg) . This activity is related to the reduction in the a ccumulation of intestinal fluid . The antidiarrheal activity can be attributed to chemical compounds already isolated and quantified in this species, mainly alkaloids.","abstract_html":"Cissampelos sympodialis (Menispermaceae), known as "Milona" have a special verified medicinal use for the treatment of diarrhea and respiratory tract diseases. This species is rich in alkaloids , secondary metabolites that add the most diverse pharmacolo gical activities , among alkaloids isolated from C. sympodialis out to warifteíne and metilwarifteíne . This study aims to evaluate the antimotility and antidiarrheal activity of the crude ethanolic extract obtained from aerial parts of C. sympodialis (EtOH E - Cs ), by means of models of gastric emptying , intestinal normal transit and castor oil - induced diarrhea. The first two models evaluated the antimotility activity whi le the model of castor oil - induced diarrhea was used to evaluate the antidiarrheal activit y by means of the latter was investigated the possible mechanism of action of antidiarrheal activity of the species under study. The results indicated that the EtOHE - Cs not shown antimotility activity but showed antidiarrheal activity (at the dose of 500 m g/kg) . This activity is related to the reduction in the a ccumulation of intestinal fluid . The antidiarrheal activity can be attributed to chemical compounds already isolated and quantified in this species, mainly alkaloids.","abstract_has_math":false,"creators":["Sales, Igor Rafael Praxedes de"],"institution":"Universidade Federal da Paraíba","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-07-22","date_published":"2014-07-22","updated_at":"2026-07-24T01:18:00Z","subjects":["Motilidade gastrintestinal","Menispermacea","Atividades farmacológicas"],"languages":["pt"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://repositorio.ufpb.br/jspui/handle/123456789/602","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Sales, Igor Rafael Praxedes de"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-22T13:39:36Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-22T13:39:36Z"]},{"key":"dc:date.issued","label":"Date","values":["2014-07-22"]},{"key":"dc:publisher","label":"Institution","values":["Universidade Federal da Paraíba"]},{"key":"dc:type","label":"Dc Type","values":["TCC"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Motilidade gastrintestinal","Menispermacea","Atividades farmacológicas"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["pt"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://repositorio.ufpb.br/jspui/handle/123456789/602"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Cissampelos sympodialis (Menispermaceae), known as \"Milona\" have a special verified medicinal use for the treatment of diarrhea and respiratory tract diseases. This species is rich in alkaloids , secondary metabolites that add the most diverse pharmacolo gical activities , among alkaloids isolated from C. sympodialis out to warifteíne and metilwarifteíne . This study aims to evaluate the antimotility and antidiarrheal activity of the crude ethanolic extract obtained from aerial parts of C. sympodialis (EtOH E - Cs ), by means of models of gastric emptying , intestinal normal transit and castor oil - induced diarrhea. The first two models evaluated the antimotility activity whi le the model of castor oil - induced diarrhea was used to evaluate the antidiarrheal activit y by means of the latter was investigated the possible mechanism of action of antidiarrheal activity of the species under study. The results indicated that the EtOHE - Cs not shown antimotility activity but showed antidiarrheal activity (at the dose of 500 m g/kg) . This activity is related to the reduction in the a ccumulation of intestinal fluid . The antidiarrheal activity can be attributed to chemical compounds already isolated and quantified in this species, mainly alkaloids."]},{"key":"dc:title","label":"Title","values":["Cissampelos sympodialis EICHL. (Menispermaceae): avaliação das atividades antimotilidade e antidiarreica in vivo."]}]}],"canonical_facts":{"dc:creator":["Sales, Igor Rafael Praxedes de"],"dc:date.accessioned":["2014-07-22T13:39:36Z"],"dc:date.available":["2014-07-22T13:39:36Z"],"dc:date.issued":["2014-07-22"],"dc:description.abstract":["Cissampelos sympodialis (Menispermaceae), known as \"Milona\" have a special verified medicinal use for the treatment of diarrhea and respiratory tract diseases. This species is rich in alkaloids , secondary metabolites that add the most diverse pharmacolo gical activities , among alkaloids isolated from C. sympodialis out to warifteíne and metilwarifteíne . This study aims to evaluate the antimotility and antidiarrheal activity of the crude ethanolic extract obtained from aerial parts of C. sympodialis (EtOH E - Cs ), by means of models of gastric emptying , intestinal normal transit and castor oil - induced diarrhea. The first two models evaluated the antimotility activity whi le the model of castor oil - induced diarrhea was used to evaluate the antidiarrheal activit y by means of the latter was investigated the possible mechanism of action of antidiarrheal activity of the species under study. The results indicated that the EtOHE - Cs not shown antimotility activity but showed antidiarrheal activity (at the dose of 500 m g/kg) . This activity is related to the reduction in the a ccumulation of intestinal fluid . The antidiarrheal activity can be attributed to chemical compounds already isolated and quantified in this species, mainly alkaloids."],"dc:identifier.uri":["https://repositorio.ufpb.br/jspui/handle/123456789/602"],"dc:language.iso":["pt"],"dc:publisher":["Universidade Federal da Paraíba"],"dc:subject":["Motilidade gastrintestinal","Menispermacea","Atividades farmacológicas"],"dc:title":["Cissampelos sympodialis EICHL. (Menispermaceae): avaliação das atividades antimotilidade e antidiarreica in vivo."],"dc:type":["TCC"]},"updated_at":"2026-07-24T01:18:00Z"}