{"id":{"repo_id":"brazil-uff","oai_identifier":"oai:app.uff.br:1/21036"},"canonical_url":"https://search.dev.ndltd.org/etd/brazil-uff/oai:app.uff.br:1/21036","repository":{"repo_id":"brazil-uff","name":"Brazil UFF","base_url":"https://app.uff.br/oai/request"},"display":{"title":"SÍNTESE DE NOVOS POTENCIAIS ANTAGONISTAS DO NMDA SUBTIPO NR2B DO SISTEMA NERVOSO CENTRAL BASEADOS EM CARBOXAMIDAS TRIAZÓLICAS","abstract":"In this work were investigated the preparations of new amines and amides 1,2,3 - and 1,2,4 - triazoles, which were viewed as intermediates in the syntheses of new amino carboxamides with potentials antagonistic activities of the N-methyl-D-aspartate in the central nervous system. While the 3-amine-5-trifluoromethyl-2H-1,2,4-triazole (2) was prepared in one step starting from the trifluoroacetic acid, the 4-aminemethyil-2-phenyl-2H-[1,2,3]-triazole (4) was synthesized in good global yield starting from the D-glucose in a route intermediated by the 2- phenyl-2H-[1,2,3]-triazole-4-carboxaldehyde (6). Once the reductive amination of 6 didn't produce the benzyl-(2-phenyl-2H- [1,2,3(triazole-4-ylmethyl)-amine (3), the preparation of this substance was investigated by the reduction of N-benzyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide (7). Because the 3-amine-5-trifluoromethyl-2H-1,2,4-triazole (2) was shown to be inert from the acylations with chlorides acids and anhydrides, the preparation of the intermediate 2- chlorine-N-(5-trifluoromethyl-2H-[1,2,4]triazole-3-yl)-acetamide (1) it was made by reaction of 2 with the chloroacetic acid in solid phase.","abstract_html":"In this work were investigated the preparations of new amines and amides 1,2,3 - and 1,2,4 - triazoles, which were viewed as intermediates in the syntheses of new amino carboxamides with potentials antagonistic activities of the N-methyl-D-aspartate in the central nervous system. While the 3-amine-5-trifluoromethyl-2H-1,2,4-triazole (2) was prepared in one step starting from the trifluoroacetic acid, the 4-aminemethyil-2-phenyl-2H-[1,2,3]-triazole (4) was synthesized in good global yield starting from the D-glucose in a route intermediated by the 2- phenyl-2H-[1,2,3]-triazole-4-carboxaldehyde (6). Once the reductive amination of 6 didn't produce the benzyl-(2-phenyl-2H- [1,2,3(triazole-4-ylmethyl)-amine (3), the preparation of this substance was investigated by the reduction of N-benzyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide (7). Because the 3-amine-5-trifluoromethyl-2H-1,2,4-triazole (2) was shown to be inert from the acylations with chlorides acids and anhydrides, the preparation of the intermediate 2- chlorine-N-(5-trifluoromethyl-2H-[1,2,4]triazole-3-yl)-acetamide (1) it was made by reaction of 2 with the chloroacetic acid in solid phase.","abstract_has_math":false,"creators":["Epifanio, Neide Mara de Menezes"],"institution":"Programa de Pós-graduação em Química Orgânica","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006-03-17","date_published":"2006-03-17","updated_at":"2026-07-27T19:00:56Z","subjects":["SNC","NMDA","carboxamidas","Neurofarmacologia","Antagonista","Triazol","Antagonista NR2B","CNS","carboxamides"],"languages":["por"],"rights":["Acesso Aberto"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://app.uff.br/riuff/handle/1/21036","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Epifanio, Neide Mara de Menezes"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2021-03-10T20:51:49Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2007-03-21","2021-03-10T20:51:49Z"]},{"key":"dc:date.issued","label":"Date","values":["2006-03-17"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Química Orgânica"]},{"key":"dc:type","label":"Dc Type","values":["Dissertação"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["SNC","NMDA","carboxamidas","Neurofarmacologia","Antagonista","Triazol","Antagonista NR2B","CNS","carboxamides"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["por"]},{"key":"dc:rights","label":"Dc Rights","values":["Acesso Aberto"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://app.uff.br/riuff/handle/1/21036"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["In this work were investigated the preparations of new amines and amides 1,2,3 - and 1,2,4 - triazoles, which were viewed as intermediates in the syntheses of new amino carboxamides with potentials antagonistic activities of the N-methyl-D-aspartate in the central nervous system. While the 3-amine-5-trifluoromethyl-2H-1,2,4-triazole (2) was prepared in one step starting from the trifluoroacetic acid, the 4-aminemethyil-2-phenyl-2H-[1,2,3]-triazole (4) was synthesized in good global yield starting from the D-glucose in a route intermediated by the 2- phenyl-2H-[1,2,3]-triazole-4-carboxaldehyde (6). Once the reductive amination of 6 didn't produce the benzyl-(2-phenyl-2H- [1,2,3(triazole-4-ylmethyl)-amine (3), the preparation of this substance was investigated by the reduction of N-benzyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide (7). Because the 3-amine-5-trifluoromethyl-2H-1,2,4-triazole (2) was shown to be inert from the acylations with chlorides acids and anhydrides, the preparation of the intermediate 2- chlorine-N-(5-trifluoromethyl-2H-[1,2,4]triazole-3-yl)-acetamide (1) it was made by reaction of 2 with the chloroacetic acid in solid phase."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["SÍNTESE DE NOVOS POTENCIAIS ANTAGONISTAS DO NMDA SUBTIPO NR2B DO SISTEMA NERVOSO CENTRAL BASEADOS EM CARBOXAMIDAS TRIAZÓLICAS"]}]}],"canonical_facts":{"dc:creator":["Epifanio, Neide Mara de Menezes"],"dc:date.accessioned":["2021-03-10T20:51:49Z"],"dc:date.available":["2007-03-21","2021-03-10T20:51:49Z"],"dc:date.issued":["2006-03-17"],"dc:description.abstract":["In this work were investigated the preparations of new amines and amides 1,2,3 - and 1,2,4 - triazoles, which were viewed as intermediates in the syntheses of new amino carboxamides with potentials antagonistic activities of the N-methyl-D-aspartate in the central nervous system. While the 3-amine-5-trifluoromethyl-2H-1,2,4-triazole (2) was prepared in one step starting from the trifluoroacetic acid, the 4-aminemethyil-2-phenyl-2H-[1,2,3]-triazole (4) was synthesized in good global yield starting from the D-glucose in a route intermediated by the 2- phenyl-2H-[1,2,3]-triazole-4-carboxaldehyde (6). Once the reductive amination of 6 didn't produce the benzyl-(2-phenyl-2H- [1,2,3(triazole-4-ylmethyl)-amine (3), the preparation of this substance was investigated by the reduction of N-benzyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide (7). Because the 3-amine-5-trifluoromethyl-2H-1,2,4-triazole (2) was shown to be inert from the acylations with chlorides acids and anhydrides, the preparation of the intermediate 2- chlorine-N-(5-trifluoromethyl-2H-[1,2,4]triazole-3-yl)-acetamide (1) it was made by reaction of 2 with the chloroacetic acid in solid phase."],"dc:format":["application/pdf"],"dc:identifier.uri":["https://app.uff.br/riuff/handle/1/21036"],"dc:language":["por"],"dc:publisher.department":["Química Orgânica"],"dc:rights":["Acesso Aberto"],"dc:subject":["SNC","NMDA","carboxamidas","Neurofarmacologia","Antagonista","Triazol","Antagonista NR2B","CNS","carboxamides"],"dc:title":["SÍNTESE DE NOVOS POTENCIAIS ANTAGONISTAS DO NMDA SUBTIPO NR2B DO SISTEMA NERVOSO CENTRAL BASEADOS EM CARBOXAMIDAS TRIAZÓLICAS"],"dc:type":["Dissertação"]},"updated_at":"2026-07-27T19:00:56Z"}