{"id":{"repo_id":"brazil-uff","oai_identifier":"oai:app.uff.br:1/18067"},"canonical_url":"https://search.dev.ndltd.org/etd/brazil-uff/oai:app.uff.br:1/18067","repository":{"repo_id":"brazil-uff","name":"Brazil UFF","base_url":"https://app.uff.br/oai/request"},"display":{"title":"ESTUDOS VISANDO A SÍNTESE DE DIAMINAS DERIVADAS DE PINENOS COM POTENCIAIS ATIVIDADES NOS RECEPTORES NICOTÍNICOS DO SISTEMA NERVOSO CENTRAL","abstract":"In this work are described the attempts of generating stereoselective syntheses of the 1,2,3-triazolic and piridine amines Ia,b-IVa,b, which constitutes in new analogous of the nicotine with potential activities as agonists of the nicotinic receptors. All the substances aimed are nicotinic analogous and the parameter of distance between the nitrogens sp2 and sp3 of these molecules was evaluated by molecular modeling in way half-empiricist AM1 method. The ketones 2a,b had been prepared from (+)-nopinone in a synthetic sequence starting the aldol condensation reaction with aldehydes 6 and 7, followed by a stereoselective reduction to the corresponding ketones 1a,b. Later some unfruitful attempts of reductive amination had been carried through. So it had been produced the oximes 4a,b and 3a for latter attempts of reduction to obtain the amino compounds IIa,b and IVa that had shown unproductive and it will be better studied in the next future..","abstract_html":"In this work are described the attempts of generating stereoselective syntheses of the 1,2,3-triazolic and piridine amines Ia,b-IVa,b, which constitutes in new analogous of the nicotine with potential activities as agonists of the nicotinic receptors. All the substances aimed are nicotinic analogous and the parameter of distance between the nitrogens sp2 and sp3 of these molecules was evaluated by molecular modeling in way half-empiricist AM1 method. The ketones 2a,b had been prepared from (+)-nopinone in a synthetic sequence starting the aldol condensation reaction with aldehydes 6 and 7, followed by a stereoselective reduction to the corresponding ketones 1a,b. Later some unfruitful attempts of reductive amination had been carried through. So it had been produced the oximes 4a,b and 3a for latter attempts of reduction to obtain the amino compounds IIa,b and IVa that had shown unproductive and it will be better studied in the next future..","abstract_has_math":false,"creators":["Rosa, Sandro Guimarães Viveiros"],"institution":"Programa de Pós-graduação em Química Orgânica","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006-10-05","date_published":"2006-10-05","updated_at":"2026-07-27T19:00:24Z","subjects":["Síntese orgânica","Receptores nicotínicos","Sistema nervoso centtal","Pineno","Diamina","Organic synthesis","nicotinic receptors","central nervous system","Pinene","Diamine"],"languages":["por"],"rights":["Acesso Aberto"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://app.uff.br/riuff/handle/1/18067","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Rosa, Sandro Guimarães Viveiros"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2021-03-10T20:43:30Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2008-11-07","2021-03-10T20:43:30Z"]},{"key":"dc:date.issued","label":"Date","values":["2006-10-05"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Química Orgânica"]},{"key":"dc:type","label":"Dc Type","values":["Dissertação"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Síntese orgânica","Receptores nicotínicos","Sistema nervoso centtal","Pineno","Diamina","Organic synthesis","nicotinic receptors","central nervous system","Pinene","Diamine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["por"]},{"key":"dc:rights","label":"Dc Rights","values":["Acesso Aberto"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://app.uff.br/riuff/handle/1/18067"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["In this work are described the attempts of generating stereoselective syntheses of the 1,2,3-triazolic and piridine amines Ia,b-IVa,b, which constitutes in new analogous of the nicotine with potential activities as agonists of the nicotinic receptors. All the substances aimed are nicotinic analogous and the parameter of distance between the nitrogens sp2 and sp3 of these molecules was evaluated by molecular modeling in way half-empiricist AM1 method. The ketones 2a,b had been prepared from (+)-nopinone in a synthetic sequence starting the aldol condensation reaction with aldehydes 6 and 7, followed by a stereoselective reduction to the corresponding ketones 1a,b. Later some unfruitful attempts of reductive amination had been carried through. So it had been produced the oximes 4a,b and 3a for latter attempts of reduction to obtain the amino compounds IIa,b and IVa that had shown unproductive and it will be better studied in the next future.."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["ESTUDOS VISANDO A SÍNTESE DE DIAMINAS DERIVADAS DE PINENOS COM POTENCIAIS ATIVIDADES NOS RECEPTORES NICOTÍNICOS DO SISTEMA NERVOSO CENTRAL"]}]}],"canonical_facts":{"dc:creator":["Rosa, Sandro Guimarães Viveiros"],"dc:date.accessioned":["2021-03-10T20:43:30Z"],"dc:date.available":["2008-11-07","2021-03-10T20:43:30Z"],"dc:date.issued":["2006-10-05"],"dc:description.abstract":["In this work are described the attempts of generating stereoselective syntheses of the 1,2,3-triazolic and piridine amines Ia,b-IVa,b, which constitutes in new analogous of the nicotine with potential activities as agonists of the nicotinic receptors. All the substances aimed are nicotinic analogous and the parameter of distance between the nitrogens sp2 and sp3 of these molecules was evaluated by molecular modeling in way half-empiricist AM1 method. The ketones 2a,b had been prepared from (+)-nopinone in a synthetic sequence starting the aldol condensation reaction with aldehydes 6 and 7, followed by a stereoselective reduction to the corresponding ketones 1a,b. Later some unfruitful attempts of reductive amination had been carried through. So it had been produced the oximes 4a,b and 3a for latter attempts of reduction to obtain the amino compounds IIa,b and IVa that had shown unproductive and it will be better studied in the next future.."],"dc:format":["application/pdf"],"dc:identifier.uri":["https://app.uff.br/riuff/handle/1/18067"],"dc:language":["por"],"dc:publisher.department":["Química Orgânica"],"dc:rights":["Acesso Aberto"],"dc:subject":["Síntese orgânica","Receptores nicotínicos","Sistema nervoso centtal","Pineno","Diamina","Organic synthesis","nicotinic receptors","central nervous system","Pinene","Diamine"],"dc:title":["ESTUDOS VISANDO A SÍNTESE DE DIAMINAS DERIVADAS DE PINENOS COM POTENCIAIS ATIVIDADES NOS RECEPTORES NICOTÍNICOS DO SISTEMA NERVOSO CENTRAL"],"dc:type":["Dissertação"]},"updated_at":"2026-07-27T19:00:24Z"}