{"id":{"repo_id":"brazil-ufba","oai_identifier":"oai:repositorio.ufba.br:ri/43841"},"canonical_url":"https://search.dev.ndltd.org/etd/brazil-ufba/oai:repositorio.ufba.br:ri/43841","repository":{"repo_id":"brazil-ufba","name":"Brazil UFBA","base_url":"https://repositorio.ufba.br/oai/request"},"display":{"title":"Doença de Whipple e endocardite tricúspide: um relato de caso","abstract":"Whipple’s disease (WD) is a rare condition of multiple clinical manifestations and difficult diagnosis. Despite being a disease of insidious evolution, it is frequently neglected and, if not treated, can progress with important sequelae and even death. Diagnosis of WD depends on clinical suspicion, exclusion of alternative conditions and of the use of invasive techniques, which makes its confirmation especially difficult in the localized forms. Although, with correct diagnosis and precocious treatment, it tends to evolve with good control of symptoms and favorable prognosis. We report the case of a male patient of 42 years of age that presented with chronic diarrhea for over 1 year associated with diffuse arthralgia, weight loss and mesenteric adenopathy. The diagnosis of WD was confirmed by digestive endoscopy and duodenal biopsy and complimentary evaluation showed associated tricuspid valve endocarditis. With treatment for WD the patient showed resolution of classic symptomatology as well as regression of the valvular vegetations. This study reports a case of WD with classic manifestation associated with isolated tricúspide valve endocarditis in a patient treated in a reference hospital in Salvador, Bahia, in Brazil. Furthermore, it discusses the challenges associated with the diagnosis and treatment of WD, especially regarding the main cardiovascular manifestation: endocarditis.","abstract_html":"Whipple’s disease (WD) is a rare condition of multiple clinical manifestations and difficult diagnosis. Despite being a disease of insidious evolution, it is frequently neglected and, if not treated, can progress with important sequelae and even death. Diagnosis of WD depends on clinical suspicion, exclusion of alternative conditions and of the use of invasive techniques, which makes its confirmation especially difficult in the localized forms. Although, with correct diagnosis and precocious treatment, it tends to evolve with good control of symptoms and favorable prognosis. We report the case of a male patient of 42 years of age that presented with chronic diarrhea for over 1 year associated with diffuse arthralgia, weight loss and mesenteric adenopathy. The diagnosis of WD was confirmed by digestive endoscopy and duodenal biopsy and complimentary evaluation showed associated tricuspid valve endocarditis. With treatment for WD the patient showed resolution of classic symptomatology as well as regression of the valvular vegetations. This study reports a case of WD with classic manifestation associated with isolated tricúspide valve endocarditis in a patient treated in a reference hospital in Salvador, Bahia, in Brazil. Furthermore, it discusses the challenges associated with the diagnosis and treatment of WD, especially regarding the main cardiovascular manifestation: endocarditis.","abstract_has_math":false,"creators":["Guimarães, Adriano Augusto Teixeira"],"institution":"Hospital Universitário Professor Edgard Santos","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-12-18","date_published":"2025-12-18","updated_at":"2026-07-27T22:07:56Z","subjects":["Doença de whipple","Tropheryma whipplei","Endocardite","Endocardite infecciosa","Endocardite de valva tricúspide"],"languages":["por"],"rights":["Acesso Restrito"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://repositorio.ufba.br/handle/ri/43841","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Guimarães, Adriano Augusto Teixeira"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2026-01-21T19:27:54Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2027-09-18","2026-01-21T19:27:54Z"]},{"key":"dc:date.issued","label":"Date","values":["2025-12-18"]},{"key":"dc:publisher","label":"Institution","values":["Hospital Universitário Professor Edgard Santos"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Faculdade de Medicina da Bahia"]},{"key":"dc:type","label":"Dc Type","values":["Trabalho de Conclusão de Curso"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Doença de whipple","Tropheryma whipplei","Endocardite","Endocardite infecciosa","Endocardite de valva tricúspide"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["por"]},{"key":"dc:rights","label":"Dc Rights","values":["Acesso Restrito"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://repositorio.ufba.br/handle/ri/43841"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Whipple’s disease (WD) is a rare condition of multiple clinical manifestations and difficult diagnosis. Despite being a disease of insidious evolution, it is frequently neglected and, if not treated, can progress with important sequelae and even death. Diagnosis of WD depends on clinical suspicion, exclusion of alternative conditions and of the use of invasive techniques, which makes its confirmation especially difficult in the localized forms. Although, with correct diagnosis and precocious treatment, it tends to evolve with good control of symptoms and favorable prognosis. We report the case of a male patient of 42 years of age that presented with chronic diarrhea for over 1 year associated with diffuse arthralgia, weight loss and mesenteric adenopathy. The diagnosis of WD was confirmed by digestive endoscopy and duodenal biopsy and complimentary evaluation showed associated tricuspid valve endocarditis. With treatment for WD the patient showed resolution of classic symptomatology as well as regression of the valvular vegetations. This study reports a case of WD with classic manifestation associated with isolated tricúspide valve endocarditis in a patient treated in a reference hospital in Salvador, Bahia, in Brazil. Furthermore, it discusses the challenges associated with the diagnosis and treatment of WD, especially regarding the main cardiovascular manifestation: endocarditis."]},{"key":"dc:title","label":"Title","values":["Doença de Whipple e endocardite tricúspide: um relato de caso"]}]}],"canonical_facts":{"dc:creator":["Guimarães, Adriano Augusto Teixeira"],"dc:date.accessioned":["2026-01-21T19:27:54Z"],"dc:date.available":["2027-09-18","2026-01-21T19:27:54Z"],"dc:date.issued":["2025-12-18"],"dc:description.abstract":["Whipple’s disease (WD) is a rare condition of multiple clinical manifestations and difficult diagnosis. Despite being a disease of insidious evolution, it is frequently neglected and, if not treated, can progress with important sequelae and even death. Diagnosis of WD depends on clinical suspicion, exclusion of alternative conditions and of the use of invasive techniques, which makes its confirmation especially difficult in the localized forms. Although, with correct diagnosis and precocious treatment, it tends to evolve with good control of symptoms and favorable prognosis. We report the case of a male patient of 42 years of age that presented with chronic diarrhea for over 1 year associated with diffuse arthralgia, weight loss and mesenteric adenopathy. The diagnosis of WD was confirmed by digestive endoscopy and duodenal biopsy and complimentary evaluation showed associated tricuspid valve endocarditis. With treatment for WD the patient showed resolution of classic symptomatology as well as regression of the valvular vegetations. This study reports a case of WD with classic manifestation associated with isolated tricúspide valve endocarditis in a patient treated in a reference hospital in Salvador, Bahia, in Brazil. Furthermore, it discusses the challenges associated with the diagnosis and treatment of WD, especially regarding the main cardiovascular manifestation: endocarditis."],"dc:identifier.uri":["https://repositorio.ufba.br/handle/ri/43841"],"dc:language":["por"],"dc:publisher":["Hospital Universitário Professor Edgard Santos"],"dc:publisher.department":["Faculdade de Medicina da Bahia"],"dc:rights":["Acesso Restrito"],"dc:subject":["Doença de whipple","Tropheryma whipplei","Endocardite","Endocardite infecciosa","Endocardite de valva tricúspide"],"dc:title":["Doença de Whipple e endocardite tricúspide: um relato de caso"],"dc:type":["Trabalho de Conclusão de Curso"]},"updated_at":"2026-07-27T22:07:56Z"}