{"id":{"repo_id":"bradford","oai_identifier":"oai:bradscholars.brad.ac.uk:10454/14426"},"canonical_url":"https://search.dev.ndltd.org/etd/bradford/oai:bradscholars.brad.ac.uk:10454/14426","repository":{"repo_id":"bradford","name":"University of Bradford","base_url":"https://bradscholars.brad.ac.uk/oai/request"},"display":{"title":"The Functional Dissection of Motion Processing Pathways in the Human Visual Cortex Using fMRI-Guided TMS","abstract":"Motion-selectivity in human visual cortex comprises a number of different cortical loci including V1, V2, V3A, V3B, hV5/MT+ and V6 (Wandell et al., 2007). This thesis sought to investigate the specific functions of V3A and sub-divisions of hV5/MT+ (TO-1 and TO-2) by using transcranial magnetic stimulation (TMS) to transiently disrupt cortical activations within these areas during psychophysical tasks of motion perception. The tasks were chosen to coincide with previous non-human primate and human neuroimaging literature; translational, radial and rotational direction discrimination tasks and identification of the position of a focus of expansion. These results assert that TO-1 and TO-2 are functionally distinct subdivisions of hV5/MT+, as we have shown that both TO-1 and TO-2 are responsible for processing translational motion direction whilst only TO-2 is responsible for processing radial motion direction. In ipsilateral space, it was found that TO-1 and TO-2 both contribute to the processing of ipsilateral translational motion. Taken in a wider context, further results also suggested that these areas may form part of a network of cortical areas contributing to perception of self-motion (heading/egomotion), as TO-2 was not found to be responsible for processing the position of the central focus of expansion (imperative for self-direction). Instead, area V3A has been implicated as functionally responsible for processing this attribute of vision. Overall it is clear that TO-1, TO-2 and V3A have specific, distinct functions that contribute towards both parallel and serial motion processing pathways within the human brain.","abstract_html":"Motion-selectivity in human visual cortex comprises a number of different cortical loci including V1, V2, V3A, V3B, hV5/MT+ and V6 (Wandell et al., 2007). This thesis sought to investigate the specific functions of V3A and sub-divisions of hV5/MT+ (TO-1 and TO-2) by using transcranial magnetic stimulation (TMS) to transiently disrupt cortical activations within these areas during psychophysical tasks of motion perception. The tasks were chosen to coincide with previous non-human primate and human neuroimaging literature; translational, radial and rotational direction discrimination tasks and identification of the position of a focus of expansion. These results assert that TO-1 and TO-2 are functionally distinct subdivisions of hV5/MT+, as we have shown that both TO-1 and TO-2 are responsible for processing translational motion direction whilst only TO-2 is responsible for processing radial motion direction. In ipsilateral space, it was found that TO-1 and TO-2 both contribute to the processing of ipsilateral translational motion. Taken in a wider context, further results also suggested that these areas may form part of a network of cortical areas contributing to perception of self-motion (heading/egomotion), as TO-2 was not found to be responsible for processing the position of the central focus of expansion (imperative for self-direction). Instead, area V3A has been implicated as functionally responsible for processing this attribute of vision. Overall it is clear that TO-1, TO-2 and V3A have specific, distinct functions that contribute towards both parallel and serial motion processing pathways within the human brain.","abstract_has_math":false,"creators":["Strong, Samantha Louise"],"institution":"University of Bradford","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["McKeefry, Declan J."],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015","date_published":"2015","updated_at":"2026-07-24T01:13:57Z","subjects":["V5/MT; Function; TO-1; TO-2; Motion perception; V3A; Functional magnetic resonance imaging (fMRI); Transcranial magnetic stimulation (TMS)"],"languages":["en"],"rights":["\"Creative
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The University of Bradford theses are licenced under a Creative Commons Licence."],"dc:subject":["V5/MT; Function; TO-1; TO-2; Motion perception; V3A; Functional magnetic resonance imaging (fMRI); Transcranial magnetic stimulation (TMS)"],"dc:title":["The Functional Dissection of Motion Processing Pathways in the Human Visual Cortex Using fMRI-Guided TMS"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-24T01:13:57Z"}