{"id":{"repo_id":"birmingham","oai_identifier":"oai:etheses.bham.ac.uk:33"},"canonical_url":"https://search.dev.ndltd.org/etd/birmingham/oai:etheses.bham.ac.uk:33","repository":{"repo_id":"birmingham","name":"University of Birmingham","base_url":"https://etheses.bham.ac.uk/cgi/oai2"},"display":{"title":"Immunological responses following surgery in ulcerative colitis","abstract":"The role of serum autoantibodies, soluble adhesion molecules, plasma and mucosal cytokines were studied following surgery for ulcerative colitis (UC). A high prevalence of ANCA was found in UC but not in Crohn’s disease. ANCA positive UC sera were found to recognise a variety of antigens, namely lactoferrin, cathepsin G, enolase and elastase. Confocal microscopy revealed maximum immunofluorescence for P-ANCA to emanate from the intranuclear and not the extra-(peri) nuclear portion of the neutrophil, as currently believed. AECA, like ANCA, are also found in UC, suggesting immunological similarities with systemic vasculitis. Perhaps, UC represents a gut limited vasculitis. Persistance of ANCA, AECA, anti-EPI and antitropomyosin antibodies in the sera, several years following total colectomy, suggests that immunological mechanisms are not halted, by total colectomy. Soluble intercellular cell adhesion molecules, ICAM-1 and E-Selectin, but not VCAM-1, were found to be useful markers of disease activity in UC. Plasma levels of cytokines do not reflect disease activity, however, there is similar quantitative expression of pro-inflammatory cytokines by isolated mucosal mononuclear cells in both active UC and pouchitis, but not in nonspecific proctitis, which seems to suggest that pouchitis is not merely a complication of ileoanal pouch surgery but, that it represents reactivation of UC in ileal mucosa, which has undergone villous atrophy and colonic metaplasia.","abstract_html":"The role of serum autoantibodies, soluble adhesion molecules, plasma and mucosal cytokines were studied following surgery for ulcerative colitis (UC). A high prevalence of ANCA was found in UC but not in Crohn’s disease. ANCA positive UC sera were found to recognise a variety of antigens, namely lactoferrin, cathepsin G, enolase and elastase. Confocal microscopy revealed maximum immunofluorescence for P-ANCA to emanate from the intranuclear and not the extra-(peri) nuclear portion of the neutrophil, as currently believed. AECA, like ANCA, are also found in UC, suggesting immunological similarities with systemic vasculitis. Perhaps, UC represents a gut limited vasculitis. Persistance of ANCA, AECA, anti-EPI and antitropomyosin antibodies in the sera, several years following total colectomy, suggests that immunological mechanisms are not halted, by total colectomy. Soluble intercellular cell adhesion molecules, ICAM-1 and E-Selectin, but not VCAM-1, were found to be useful markers of disease activity in UC. Plasma levels of cytokines do not reflect disease activity, however, there is similar quantitative expression of pro-inflammatory cytokines by isolated mucosal mononuclear cells in both active UC and pouchitis, but not in nonspecific proctitis, which seems to suggest that pouchitis is not merely a complication of ileoanal pouch surgery but, that it represents reactivation of UC in ileal mucosa, which has undergone villous atrophy and colonic metaplasia.","abstract_has_math":false,"creators":["Patel, Rajan Kumar"],"institution":"University of Birmingham","degree_name":"h_md","degree_level":"h_md","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1995,"date_issued":"1995-12","date_published":"1995-12","updated_at":"2026-07-24T01:10:41Z","subjects":["RD Surgery","QR180 Immunology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://etheses.bham.ac.uk//id/eprint/33/2/Decl_IS_Patel95MD.gif","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.sponsor","label":"Sponsor","values":["na"]},{"key":"dc:creator","label":"Author","values":["Patel, Rajan Kumar"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1995-12-16"]},{"key":"dc:date.issued","label":"Date","values":["1995-12"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Faculty of Medicine and Dentistry","Department of Surgery"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Birmingham"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["http://etheses.bham.ac.uk//id/eprint/33/"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["h_md"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["h_md"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["RD Surgery","QR180 Immunology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://etheses.bham.ac.uk//id/eprint/33/1/Patel95MD.pdf","http://etheses.bham.ac.uk//id/eprint/33/2/Decl_IS_Patel95MD.gif"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The role of serum autoantibodies, soluble adhesion molecules, plasma and mucosal cytokines were studied following surgery for ulcerative colitis (UC). A high prevalence of ANCA was found in UC but not in Crohn’s disease. ANCA positive UC sera were found to recognise a variety of antigens, namely lactoferrin, cathepsin G, enolase and elastase. Confocal microscopy revealed maximum immunofluorescence for P-ANCA to emanate from the intranuclear and not the extra-(peri) nuclear portion of the neutrophil, as currently believed. AECA, like ANCA, are also found in UC, suggesting immunological similarities with systemic vasculitis. Perhaps, UC represents a gut limited vasculitis. Persistance of ANCA, AECA, anti-EPI and antitropomyosin antibodies in the sera, several years following total colectomy, suggests that immunological mechanisms are not halted, by total colectomy. Soluble intercellular cell adhesion molecules, ICAM-1 and E-Selectin, but not VCAM-1, were found to be useful markers of disease activity in UC. Plasma levels of cytokines do not reflect disease activity, however, there is similar quantitative expression of pro-inflammatory cytokines by isolated mucosal mononuclear cells in both active UC and pouchitis, but not in nonspecific proctitis, which seems to suggest that pouchitis is not merely a complication of ileoanal pouch surgery but, that it represents reactivation of UC in ileal mucosa, which has undergone villous atrophy and colonic metaplasia."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf","image/gif"]},{"key":"dc:title","label":"Title","values":["Immunological responses following surgery in ulcerative colitis"]}]}],"canonical_facts":{"dc:contributor.sponsor":["na"],"dc:creator":["Patel, Rajan Kumar"],"dc:date":["1995-12-16"],"dc:date.issued":["1995-12"],"dc:description.abstract":["The role of serum autoantibodies, soluble adhesion molecules, plasma and mucosal cytokines were studied following surgery for ulcerative colitis (UC). A high prevalence of ANCA was found in UC but not in Crohn’s disease. ANCA positive UC sera were found to recognise a variety of antigens, namely lactoferrin, cathepsin G, enolase and elastase. Confocal microscopy revealed maximum immunofluorescence for P-ANCA to emanate from the intranuclear and not the extra-(peri) nuclear portion of the neutrophil, as currently believed. AECA, like ANCA, are also found in UC, suggesting immunological similarities with systemic vasculitis. Perhaps, UC represents a gut limited vasculitis. Persistance of ANCA, AECA, anti-EPI and antitropomyosin antibodies in the sera, several years following total colectomy, suggests that immunological mechanisms are not halted, by total colectomy. Soluble intercellular cell adhesion molecules, ICAM-1 and E-Selectin, but not VCAM-1, were found to be useful markers of disease activity in UC. Plasma levels of cytokines do not reflect disease activity, however, there is similar quantitative expression of pro-inflammatory cytokines by isolated mucosal mononuclear cells in both active UC and pouchitis, but not in nonspecific proctitis, which seems to suggest that pouchitis is not merely a complication of ileoanal pouch surgery but, that it represents reactivation of UC in ileal mucosa, which has undergone villous atrophy and colonic metaplasia."],"dc:format":["application/pdf","image/gif"],"dc:identifier.uri":["http://etheses.bham.ac.uk//id/eprint/33/1/Patel95MD.pdf","http://etheses.bham.ac.uk//id/eprint/33/2/Decl_IS_Patel95MD.gif"],"dc:publisher.department":["Faculty of Medicine and Dentistry","Department of Surgery"],"dc:publisher.institution":["University of Birmingham"],"dc:relation.isreferencedby":["http://etheses.bham.ac.uk//id/eprint/33/"],"dc:subject":["RD Surgery","QR180 Immunology"],"dc:title":["Immunological responses following surgery in ulcerative colitis"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["h_md"],"dc:type.qualificationname":["h_md"]},"updated_at":"2026-07-24T01:10:41Z"}