This thesis was undertaken in order to gain a more complete understanding of the penetration of the sulfur metabolic pathways by selenium. Specifically, an attempt was made to determine if selenium could replace sulfur in biotin synthesized by Phycomyces blakesleeanus. Although selenium has been found to replace sulfur in many biologically active compounds, it has never been demonstrated in a naturally synthesized coenzyme or cyclic structure such as that found in biotin.
","abstract_html":"<p>This thesis was undertaken in order to gain a more complete understanding of the penetration of the sulfur metabolic pathways by selenium. Specifically, an attempt was made to determine if selenium could replace sulfur in biotin synthesized by Phycomyces blakesleeanus. Although selenium has been found to replace sulfur in many biologically active compounds, it has never been demonstrated in a naturally synthesized coenzyme or cyclic structure such as that found in biotin.</p>","abstract_has_math":false,"creators":["Frost, Janet Linda"],"institution":null,"degree_name":"Master of Arts (MA)","degree_level":"Thesis","degree_discipline":"Biological Sciences","degree_department":null,"school":null,"contributors":["Alex Shrift","Fredrick Kull","Bruce Norcross"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1977,"date_issued":"1977-01-01T08:00:00Z","date_published":"1977-01-01T08:00:00Z","updated_at":"2026-07-24T01:10:16Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://orb.binghamton.edu/dissertation_and_theses/425","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Alex Shrift","Fredrick Kull","Bruce Norcross"]},{"key":"dc:creator","label":"Author","values":["Frost, Janet Linda"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Biological Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Arts (MA)"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://orb.binghamton.edu/dissertation_and_theses/425"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["This thesis was undertaken in order to gain a more complete understanding of the penetration of the sulfur metabolic pathways by selenium. Specifically, an attempt was made to determine if selenium could replace sulfur in biotin synthesized by Phycomyces blakesleeanus. Although selenium has been found to replace sulfur in many biologically active compounds, it has never been demonstrated in a naturally synthesized coenzyme or cyclic structure such as that found in biotin.
"]},{"key":"dc:title","label":"Title","values":["The biosynthesis of a biotin compound containing ⁷⁵Se"]}]}],"canonical_facts":{"dc:contributor":["Alex Shrift","Fredrick Kull","Bruce Norcross"],"dc:creator":["Frost, Janet Linda"],"dc:description.abstract":["This thesis was undertaken in order to gain a more complete understanding of the penetration of the sulfur metabolic pathways by selenium. Specifically, an attempt was made to determine if selenium could replace sulfur in biotin synthesized by Phycomyces blakesleeanus. Although selenium has been found to replace sulfur in many biologically active compounds, it has never been demonstrated in a naturally synthesized coenzyme or cyclic structure such as that found in biotin.
"],"dc:identifier":["https://orb.binghamton.edu/dissertation_and_theses/425"],"dc:title":["The biosynthesis of a biotin compound containing ⁷⁵Se"],"thesis:degree_discipline":["Biological Sciences"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Arts (MA)"]},"updated_at":"2026-07-24T01:10:16Z"}