The original purpose of this investigation was to prepare and isolate selenobiotin. Several attempts were made to prepare 3-(-carboxymethylseleno-)-alanine, a critical intermediate in the proposed synthetic sequence, without success. In view of this unexpected difficulty, the object of the research was changed to the synthesis of cis-3,4-ureyleneselenophane, the parent fused heterocyclic system. The formation of this molecule has been realized, and alternate pathways have been tested which establish a model system for the synthesis of selenobiotin.
","abstract_html":"<p>The original purpose of this investigation was to prepare and isolate selenobiotin. Several attempts were made to prepare 3-(-carboxymethylseleno-)-alanine, a critical intermediate in the proposed synthetic sequence, without success. In view of this unexpected difficulty, the object of the research was changed to the synthesis of <i>cis</i>-3,4-ureyleneselenophane, the parent fused heterocyclic system. The formation of this molecule has been realized, and alternate pathways have been tested which establish a model system for the synthesis of selenobiotin.</p>","abstract_has_math":false,"creators":["Martin, Robert L."],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Walter E. Kaskan","Bruce E. Norcross","Howard Alper"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1974,"date_issued":"1974-01-01T08:00:00Z","date_published":"1974-01-01T08:00:00Z","updated_at":"2026-07-24T01:10:16Z","subjects":["Organoselenium compounds"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://orb.binghamton.edu/dissertation_and_theses/230","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Walter E. Kaskan","Bruce E. Norcross","Howard Alper"]},{"key":"dc:creator","label":"Author","values":["Martin, Robert L."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Organoselenium compounds"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://orb.binghamton.edu/dissertation_and_theses/230"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The original purpose of this investigation was to prepare and isolate selenobiotin. Several attempts were made to prepare 3-(-carboxymethylseleno-)-alanine, a critical intermediate in the proposed synthetic sequence, without success. In view of this unexpected difficulty, the object of the research was changed to the synthesis of cis-3,4-ureyleneselenophane, the parent fused heterocyclic system. The formation of this molecule has been realized, and alternate pathways have been tested which establish a model system for the synthesis of selenobiotin.
"]},{"key":"dc:title","label":"Title","values":["Reactions directed towards the synthesis of selenobiotin"]}]}],"canonical_facts":{"dc:contributor":["Walter E. Kaskan","Bruce E. Norcross","Howard Alper"],"dc:creator":["Martin, Robert L."],"dc:description.abstract":["The original purpose of this investigation was to prepare and isolate selenobiotin. Several attempts were made to prepare 3-(-carboxymethylseleno-)-alanine, a critical intermediate in the proposed synthetic sequence, without success. In view of this unexpected difficulty, the object of the research was changed to the synthesis of cis-3,4-ureyleneselenophane, the parent fused heterocyclic system. The formation of this molecule has been realized, and alternate pathways have been tested which establish a model system for the synthesis of selenobiotin.
"],"dc:identifier":["https://orb.binghamton.edu/dissertation_and_theses/230"],"dc:subject":["Organoselenium compounds"],"dc:title":["Reactions directed towards the synthesis of selenobiotin"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T01:10:16Z"}