Heritable variation in reward sensitivity and impulsive cction and choice in a genetically diverse inbred mouse panel

<p>Research in animal models and human subjects points towards reward sensitivity and impulsivity as being characteristics that predict greater positive subjective responses to stimulant drugs. The Collaborative Cross (CC) recombinant inbred mouse strains and their inbred founders are a powerful genetic reference panel that has potential as a tool for revealing genetic correlations. The CC/DO founder strains were used to examine the heritability of reward sensitivity and impulsivity traits. Founder strains were tested for activity in an open field, reward sensitivity, and reversal learning (impulsive action) or delay discounting (impulsive choice). Significant heritability for anticipatory responding within the reversal task, k-value within delay discounting, locomotor activity, and reward sensitivity was found. Reversal total trials to criteria was positively correlated with ethanol intake in females. This research was conducted with the Center for Systems Neurogenetics of Addiction’s (CSNA) effort to characterize CC and DO mice for multiple, cocaine abuse related traits.</p>

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Psychology

Year

2018

Author dc:creator

• Bailey, Lauren S

Contributors dc:contributor

• J. David Jentsch

• Biological sciences
• Psychology
• Addiction
• Collaborative cross
• Delay discounting
• Ethanol
• Impulsivity
• Reversal learning

Repository record dc:identifier

https://orb.binghamton.edu/dissertation_and_theses/47

OAI identifier oai:identifier

oai:orb.binghamton.edu:dissertation_and_theses-1040