{"id":{"repo_id":"baylor","oai_identifier":"oai:baylor-ir.tdl.org:2104/9894"},"canonical_url":"https://search.dev.ndltd.org/etd/baylor/oai:baylor-ir.tdl.org:2104/9894","repository":{"repo_id":"baylor","name":"Baylor University","base_url":"https://baylor-ir.tdl.org/server/oai/request"},"display":{"title":"Deletion of FMR1 results in sex-specific changes in behavior.","abstract":"Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by excessive trinucleotide (CGG) repeats in the FMR1 gene coding for fragile x mental retardation protein (FMRP). In humans, this disorder is characterized by intellectual disability, as well as other behavioral abnormalities, such as hyperactivity and social behavior abnormalities. Mutations in the FMR1 gene are found in 2 - 6 % of individuals with Autism Spectrum Disorder (ASD), making it the single largest genetic contributor to ASD. Mouse models of FXS disorder are commonly touted as preferred models for understanding ASD. Furthermore, few studies to date have examined the role of sex in the FMR1 phenotype. In the present study, we used a systemic FMR1 knockout in an FVB background strain. We examined the effects of this genetic mutation in males and females homozygous for an FMR1 mutation on measures sociability, repetitive behaviors, vocalization patterns, anxiety and fear-related learning.","abstract_html":"Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by excessive trinucleotide (CGG) repeats in the FMR1 gene coding for fragile x mental retardation protein (FMRP). In humans, this disorder is characterized by intellectual disability, as well as other behavioral abnormalities, such as hyperactivity and social behavior abnormalities. Mutations in the FMR1 gene are found in 2 - 6 % of individuals with Autism Spectrum Disorder (ASD), making it the single largest genetic contributor to ASD. Mouse models of FXS disorder are commonly touted as preferred models for understanding ASD. Furthermore, few studies to date have examined the role of sex in the FMR1 phenotype. In the present study, we used a systemic FMR1 knockout in an FVB background strain. We examined the effects of this genetic mutation in males and females homozygous for an FMR1 mutation on measures sociability, repetitive behaviors, vocalization patterns, anxiety and fear-related learning.","abstract_has_math":false,"creators":["Nolan-Strle, Suzanne O., 1991-"],"institution":"Baylor University.","degree_name":"M.A.","degree_level":"Masters","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Lugo, Joaquin N."],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016-12","date_published":"2016-12","updated_at":"2026-07-24T01:07:58Z","subjects":["Fragile X syndrome.","Autism spectrum disorder (ASD)"],"languages":["en"],"rights":["Baylor University works are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2104/9894","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Lugo, Joaquin N."]},{"key":"dc:creator","label":"Author","values":["Nolan-Strle, Suzanne O., 1991-"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-01-19T16:45:41Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2017-01-19T16:45:41Z"]},{"key":"dc:date.issued","label":"Date","values":["2016-12"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.A."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Baylor University."]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Fragile X syndrome.","Autism spectrum disorder (ASD)"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Baylor University works are protected by copyright. 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Mouse models of FXS disorder are commonly touted as preferred models for understanding ASD. Furthermore, few studies to date have examined the role of sex in the FMR1 phenotype. In the present study, we used a systemic FMR1 knockout in an FVB background strain. We examined the effects of this genetic mutation in males and females homozygous for an FMR1 mutation on measures sociability, repetitive behaviors, vocalization patterns, anxiety and fear-related learning."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Deletion of FMR1 results in sex-specific changes in behavior."]}]}],"canonical_facts":{"dc:contributor.advisor":["Lugo, Joaquin N."],"dc:creator":["Nolan-Strle, Suzanne O., 1991-"],"dc:date.accessioned":["2017-01-19T16:45:41Z"],"dc:date.available":["2017-01-19T16:45:41Z"],"dc:date.issued":["2016-12"],"dc:description.abstract":["Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by excessive trinucleotide (CGG) repeats in the FMR1 gene coding for fragile x mental retardation protein (FMRP). In humans, this disorder is characterized by intellectual disability, as well as other behavioral abnormalities, such as hyperactivity and social behavior abnormalities. Mutations in the FMR1 gene are found in 2 - 6 % of individuals with Autism Spectrum Disorder (ASD), making it the single largest genetic contributor to ASD. Mouse models of FXS disorder are commonly touted as preferred models for understanding ASD. Furthermore, few studies to date have examined the role of sex in the FMR1 phenotype. In the present study, we used a systemic FMR1 knockout in an FVB background strain. We examined the effects of this genetic mutation in males and females homozygous for an FMR1 mutation on measures sociability, repetitive behaviors, vocalization patterns, anxiety and fear-related learning."],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["https://hdl.handle.net/2104/9894"],"dc:language.iso":["en"],"dc:rights":["Baylor University works are protected by copyright. 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