Interaction between cell adhesion molecules and stress hormones following different intensities of cycling exercise in obese males.

The purpose of the current study was to examine the interaction between exercise-induced stress hormones [epinephrine (E), norepinephrine (NE), and cortisol (COR)] and soluble cell adhesion molecules [soluble intercellular adhesion molecule 1(sICAM-1), soluble vascular cell adhesion molecule 1(sVCAM-1), and soluble endothelial selectin (sE-selectin)] over 24 hours following different intensities of exercise in obese men. In a randomised, cross-over design, 15 physically inactive (physical activity < 2 days per week) obese (BMI > 30 kg/m²) men between the ages of 18-30 years performed a single bout of cycling exercise (average energy expenditure ~ 300 kcal) at two different intensities [low-intensity (LI): 50% of maximal heart rate and higher-intensity (HI): 80% of maximal heart rate] in random order. Overnight fasting blood samples were collected at baseline, immediately post-exercise (IPE), 1-hr PE, and 24-hr PE. All data were analyzed using an analysis of variance with repeated measures, along with Bonferroni multiple comparisons. A linear regression analysis was used to examine the interaction between exercise-induced stress hormones and soluble cell adhesion molecules (sCAMs) (p < .05), sICAM-1, sVCAM-1, E or NE did not change, while sE-selectin at 1-hr PE (10.25±1.07 ng/mL) significantly decreased (p = .045) from baseline (12.22±1.39 ng/mL). COR at IPE (262.12±31.09 ng/ml) was significantly higher (p = .001) than 1-hr PE (189.35±31.11 ng/ml) during HI. In contrast, COR at IPE (187.52±31.09 ng/ml, p = .009) and 1-hr PE (156.24±31.11 ng/ml, p = .001) was significantly lower than baseline (259.75±23.07 ng/ml) during LI. COR and sICAM-1 had a negative relationship at 1-hr PE during LI (r² = .34, p = .02), whereas COR and sVCAM-1 had a positive relationship at IPE during HI (r² = .36, p = .02). Additionally, there was a positive relationship between E and sE-selectin at 1-hr PE during HI (r² = .56, p = .01), and a negative relationship between COR and sE-selectin at baseline during LI and HI (r² = .32, p = .03 and r² = .70, p < .001, respectively). An exercise-induced decrease in sE-selectin observed in the current study suggests sE-selectin may be an early marker of exercise-induced immunosuppression due to epinephrine. Although sICAM-1 and sVCAM-1 did not significantly change following exercise, a significant interaction between COR and sICAM-1 and sVCAM-1 suggests COR may play a critical role in the modulation of sICAM-1 and sVCAM-1.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Doctoral

Grantor

Baylor University.

Year dc:date.issued

2016

Author dc:creator

• Park, Jinkyung, 1985-

Advisor dc:contributor.advisor

• Koh, Yunsuk.

• Stress hormone.
• Cell adhesion molecule.
• Exercise.

Statement dc:rights

• Baylor University works are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.

Language dc:language.iso

en

Handle dc:identifier.uri

https://hdl.handle.net/2104/9809

OAI identifier oai:identifier

oai:baylor-ir.tdl.org:2104/9809