{"id":{"repo_id":"baylor","oai_identifier":"oai:baylor-ir.tdl.org:2104/13754"},"canonical_url":"https://search.dev.ndltd.org/etd/baylor/oai:baylor-ir.tdl.org:2104/13754","repository":{"repo_id":"baylor","name":"Baylor University","base_url":"https://baylor-ir.tdl.org/server/oai/request"},"display":{"title":"Voluntary wheel running mitigates hyperglycemia-induced depressive-like behavior and increases hippocampal BDNF levels in male mice.","abstract":"Diabetes is associated with an increased risk for depression. Emerging data suggests this effect is partly mediated by hyperglycemia increasing neuroinflammation and decreasing neurotrophy. While exercise reduces depressive symptoms in other models of depression, limited research has investigated the efficacy of exercise-related interventions in hyperglycemia-associated depression. Thus, we examined whether chronic exercise could rescue hyperglycemia-related affective dysfunction and modulate neuroinflammatory and neurotrophic levels in male C57BL/6J mice. Hyperglycemia was induced via administration of 50 mg/kg/day streptozotocin (STZ) over 5 consecutive days. Four weeks post-STZ, mice in the exercise group had voluntary running wheel access in their home cage for 6 weeks. As anticipated, STZ induced depressive-like behavior. Exercise attenuated behavioral deficits in the forced swim and splash test. Tissue analyses found that exercise affected hippocampal neurotrophic markers, while STZ influenced cerebellar inflammatory markers. This study provides novel evidence that hyperglycemia and exercise exert brain-region-specific modulatory effects on behavioral alterations.","abstract_html":"Diabetes is associated with an increased risk for depression. Emerging data suggests this effect is partly mediated by hyperglycemia increasing neuroinflammation and decreasing neurotrophy. While exercise reduces depressive symptoms in other models of depression, limited research has investigated the efficacy of exercise-related interventions in hyperglycemia-associated depression. Thus, we examined whether chronic exercise could rescue hyperglycemia-related affective dysfunction and modulate neuroinflammatory and neurotrophic levels in male C57BL/6J mice. Hyperglycemia was induced via administration of 50 mg/kg/day streptozotocin (STZ) over 5 consecutive days. Four weeks post-STZ, mice in the exercise group had voluntary running wheel access in their home cage for 6 weeks. As anticipated, STZ induced depressive-like behavior. Exercise attenuated behavioral deficits in the forced swim and splash test. Tissue analyses found that exercise affected hippocampal neurotrophic markers, while STZ influenced cerebellar inflammatory markers. This study provides novel evidence that hyperglycemia and exercise exert brain-region-specific modulatory effects on behavioral alterations.","abstract_has_math":false,"creators":["Kusumo, Laura E., 2001-"],"institution":"Baylor University.","degree_name":"M.A.","degree_level":"Masters","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Vichaya, Elisabeth G."],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-05","date_published":"2025-05","updated_at":"2026-07-24T01:08:13Z","subjects":["Diabetes.","Mice.","Exercise.","Depression.","Brain-derived neurotrophic factor (BDNF)","Voluntary wheel running.","Streptozotocin."],"languages":["en"],"rights":["Baylor University works are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 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Thus, we examined whether chronic exercise could rescue hyperglycemia-related affective dysfunction and modulate neuroinflammatory and neurotrophic levels in male C57BL/6J mice. Hyperglycemia was induced via administration of 50 mg/kg/day streptozotocin (STZ) over 5 consecutive days. Four weeks post-STZ, mice in the exercise group had voluntary running wheel access in their home cage for 6 weeks. As anticipated, STZ induced depressive-like behavior. Exercise attenuated behavioral deficits in the forced swim and splash test. Tissue analyses found that exercise affected hippocampal neurotrophic markers, while STZ influenced cerebellar inflammatory markers. This study provides novel evidence that hyperglycemia and exercise exert brain-region-specific modulatory effects on behavioral alterations."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Voluntary wheel running mitigates hyperglycemia-induced depressive-like behavior and increases hippocampal BDNF levels in male mice."]}]}],"canonical_facts":{"dc:contributor.advisor":["Vichaya, Elisabeth G."],"dc:creator":["Kusumo, Laura E., 2001-"],"dc:date.accessioned":["2025-09-05T15:32:43Z"],"dc:date.issued":["2025-05"],"dc:description.abstract":["Diabetes is associated with an increased risk for depression. Emerging data suggests this effect is partly mediated by hyperglycemia increasing neuroinflammation and decreasing neurotrophy. While exercise reduces depressive symptoms in other models of depression, limited research has investigated the efficacy of exercise-related interventions in hyperglycemia-associated depression. Thus, we examined whether chronic exercise could rescue hyperglycemia-related affective dysfunction and modulate neuroinflammatory and neurotrophic levels in male C57BL/6J mice. Hyperglycemia was induced via administration of 50 mg/kg/day streptozotocin (STZ) over 5 consecutive days. Four weeks post-STZ, mice in the exercise group had voluntary running wheel access in their home cage for 6 weeks. As anticipated, STZ induced depressive-like behavior. Exercise attenuated behavioral deficits in the forced swim and splash test. Tissue analyses found that exercise affected hippocampal neurotrophic markers, while STZ influenced cerebellar inflammatory markers. This study provides novel evidence that hyperglycemia and exercise exert brain-region-specific modulatory effects on behavioral alterations."],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["https://hdl.handle.net/2104/13754"],"dc:language.iso":["en"],"dc:rights":["Baylor University works are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission."],"dc:subject":["Diabetes.","Mice.","Exercise.","Depression.","Brain-derived neurotrophic factor (BDNF)","Voluntary wheel running.","Streptozotocin."],"dc:title":["Voluntary wheel running mitigates hyperglycemia-induced depressive-like behavior and increases hippocampal BDNF levels in male mice."],"dc:type":["Thesis"],"thesis:degree_level":["Masters"],"thesis:degree_name":["M.A."],"thesis:institution_name":["Baylor University."]},"updated_at":"2026-07-24T01:08:13Z"}