{"id":{"repo_id":"baylor","oai_identifier":"oai:baylor-ir.tdl.org:2104/13105"},"canonical_url":"https://search.dev.ndltd.org/etd/baylor/oai:baylor-ir.tdl.org:2104/13105","repository":{"repo_id":"baylor","name":"Baylor University","base_url":"https://baylor-ir.tdl.org/server/oai/request"},"display":{"title":"Cerebrovascular and respiratory adaptations following 4 weeks of transient hypercapnic aerobic exercise.","abstract":"Background: Utilizing nasal breathing (NB) during a moderate-intensity aerobic exercise bout can elicit a hypercapnic insult that increases cerebral blood flow (CBF) and oxygen mobilization. Therefore, NB may bestow unique cerebrovascular and pulmonary adaptations. Aims: To examine if utilizing NB over 4 weeks of aerobic exercise provides superior cerebrovascular and respiratory adaptations than oronasal combined breathing (CB). Methods: 22 males (age: 21.55 ± 2.58 years) were randomly assigned (N = 11 per group) to either a CB or NB group. At visit 1 (V1, pre-study), pulmonary function was assessed [forced vital capacity (FVC), forced expiratory volume during the first second (FEV1.0), and peak expiratory flow (PEF)] alongside a graded maximal aerobic exercise test (GXT). After 4 weeks of moderate-intensity aerobic excise with their assigned breathing condition, variables were reassessed at visit 2 (V2, post-study). Pulmonary function was assessed via spirometry, and respiratory parameters were assessed via a metabolic cart. Ultrasound sonography was utilized to assess peak-systolic (PSV) and end-diastolic velocity (EDV) of the internal (ICA) and external (ECA) carotid artery. Multivariate models and mixed between-within repeated measures ANOVAs with Bonferroni corrections were utilized to analyze all data with a significance set at p < 0.05. Results: During the V2 GXT, the ICA PSV was significantly higher (p = 0.023) in the NB (71.05 ± 3.70 cm/s) group than the CB (56.00 ± 3.71 cm/s) group at 100% of VO2max. Similarly, the ICA EDV was significantly higher (p = 0.017) in the NB (17.69 ± 1.49 cm/s) group than the CB (11.30 ± 1.50 cm/s) group at 100% of VO2max. From V1 to V2, the NB group (p = 0.033) significantly improved FEV1.0 (V1: 4.33 ± 0.64 L; V2: 4.47 ± 0.67 L), while the CB group (p = 0.038) improved PEF (V1: 543.55 ± 96.41 L·min-1; V2: 588.77 ± 66.86 L·min-1). Conclusion: After 4 weeks of moderate-intensity aerobic exercise utilizing NB, our results suggest that the primary cerebrovascular adaptation achieved was related to a reduction in cerebrovascular resistance. Additionally, aerobic exercise training with NB displayed signs of greater alveolar elasticity.","abstract_html":"Background: Utilizing nasal breathing (NB) during a moderate-intensity aerobic exercise bout can elicit a hypercapnic insult that increases cerebral blood flow (CBF) and oxygen mobilization. Therefore, NB may bestow unique cerebrovascular and pulmonary adaptations. Aims: To examine if utilizing NB over 4 weeks of aerobic exercise provides superior cerebrovascular and respiratory adaptations than oronasal combined breathing (CB). Methods: 22 males (age: 21.55 ± 2.58 years) were randomly assigned (N = 11 per group) to either a CB or NB group. At visit 1 (V1, pre-study), pulmonary function was assessed [forced vital capacity (FVC), forced expiratory volume during the first second (FEV1.0), and peak expiratory flow (PEF)] alongside a graded maximal aerobic exercise test (GXT). After 4 weeks of moderate-intensity aerobic excise with their assigned breathing condition, variables were reassessed at visit 2 (V2, post-study). Pulmonary function was assessed via spirometry, and respiratory parameters were assessed via a metabolic cart. Ultrasound sonography was utilized to assess peak-systolic (PSV) and end-diastolic velocity (EDV) of the internal (ICA) and external (ECA) carotid artery. Multivariate models and mixed between-within repeated measures ANOVAs with Bonferroni corrections were utilized to analyze all data with a significance set at p < 0.05. Results: During the V2 GXT, the ICA PSV was significantly higher (p = 0.023) in the NB (71.05 ± 3.70 cm/s) group than the CB (56.00 ± 3.71 cm/s) group at 100% of VO2max. Similarly, the ICA EDV was significantly higher (p = 0.017) in the NB (17.69 ± 1.49 cm/s) group than the CB (11.30 ± 1.50 cm/s) group at 100% of VO2max. From V1 to V2, the NB group (p = 0.033) significantly improved FEV1.0 (V1: 4.33 ± 0.64 L; V2: 4.47 ± 0.67 L), while the CB group (p = 0.038) improved PEF (V1: 543.55 ± 96.41 L·min-1; V2: 588.77 ± 66.86 L·min-1). Conclusion: After 4 weeks of moderate-intensity aerobic exercise utilizing NB, our results suggest that the primary cerebrovascular adaptation achieved was related to a reduction in cerebrovascular resistance. Additionally, aerobic exercise training with NB displayed signs of greater alveolar elasticity.","abstract_has_math":false,"creators":["Seiba Moris, Jose M., 1995-"],"institution":"Baylor University.","degree_name":"Ph.D.","degree_level":"Doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Koh, Yunsuk."],"committee_chairs":[],"committee_members":[],"year":2024,"date_issued":"2024-08","date_published":"2024-08","updated_at":"2026-07-24T01:07:56Z","subjects":["Oxygen uptake.","Hypoventilation.","Hyperemia.","Partial pressure of end‑tidal CO2 (PetCO2)","Airway resistance.","Cognition."],"languages":["en"],"rights":["Baylor University works are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2104/13105","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Koh, Yunsuk."]},{"key":"dc:creator","label":"Author","values":["Seiba Moris, Jose M., 1995-"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2024-12-19T18:51:54Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2024-12-19T18:51:54Z"]},{"key":"dc:date.issued","label":"Date","values":["2024-08"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Baylor University."]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Oxygen uptake.","Hypoventilation.","Hyperemia.","Partial pressure of end‑tidal CO2 (PetCO2)","Airway resistance.","Cognition."]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Baylor University works are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/2104/13105"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Background: Utilizing nasal breathing (NB) during a moderate-intensity aerobic exercise bout can elicit a hypercapnic insult that increases cerebral blood flow (CBF) and oxygen mobilization. Therefore, NB may bestow unique cerebrovascular and pulmonary adaptations. Aims: To examine if utilizing NB over 4 weeks of aerobic exercise provides superior cerebrovascular and respiratory adaptations than oronasal combined breathing (CB). Methods: 22 males (age: 21.55 ± 2.58 years) were randomly assigned (N = 11 per group) to either a CB or NB group. At visit 1 (V1, pre-study), pulmonary function was assessed [forced vital capacity (FVC), forced expiratory volume during the first second (FEV1.0), and peak expiratory flow (PEF)] alongside a graded maximal aerobic exercise test (GXT). After 4 weeks of moderate-intensity aerobic excise with their assigned breathing condition, variables were reassessed at visit 2 (V2, post-study). Pulmonary function was assessed via spirometry, and respiratory parameters were assessed via a metabolic cart. Ultrasound sonography was utilized to assess peak-systolic (PSV) and end-diastolic velocity (EDV) of the internal (ICA) and external (ECA) carotid artery. Multivariate models and mixed between-within repeated measures ANOVAs with Bonferroni corrections were utilized to analyze all data with a significance set at p < 0.05. Results: During the V2 GXT, the ICA PSV was significantly higher (p = 0.023) in the NB (71.05 ± 3.70 cm/s) group than the CB (56.00 ± 3.71 cm/s) group at 100% of VO2max. Similarly, the ICA EDV was significantly higher (p = 0.017) in the NB (17.69 ± 1.49 cm/s) group than the CB (11.30 ± 1.50 cm/s) group at 100% of VO2max. From V1 to V2, the NB group (p = 0.033) significantly improved FEV1.0 (V1: 4.33 ± 0.64 L; V2: 4.47 ± 0.67 L), while the CB group (p = 0.038) improved PEF (V1: 543.55 ± 96.41 L·min-1; V2: 588.77 ± 66.86 L·min-1). Conclusion: After 4 weeks of moderate-intensity aerobic exercise utilizing NB, our results suggest that the primary cerebrovascular adaptation achieved was related to a reduction in cerebrovascular resistance. Additionally, aerobic exercise training with NB displayed signs of greater alveolar elasticity."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Cerebrovascular and respiratory adaptations following 4 weeks of transient hypercapnic aerobic exercise."]}]}],"canonical_facts":{"dc:contributor.advisor":["Koh, Yunsuk."],"dc:creator":["Seiba Moris, Jose M., 1995-"],"dc:date.accessioned":["2024-12-19T18:51:54Z"],"dc:date.available":["2024-12-19T18:51:54Z"],"dc:date.issued":["2024-08"],"dc:description.abstract":["Background: Utilizing nasal breathing (NB) during a moderate-intensity aerobic exercise bout can elicit a hypercapnic insult that increases cerebral blood flow (CBF) and oxygen mobilization. Therefore, NB may bestow unique cerebrovascular and pulmonary adaptations. Aims: To examine if utilizing NB over 4 weeks of aerobic exercise provides superior cerebrovascular and respiratory adaptations than oronasal combined breathing (CB). Methods: 22 males (age: 21.55 ± 2.58 years) were randomly assigned (N = 11 per group) to either a CB or NB group. At visit 1 (V1, pre-study), pulmonary function was assessed [forced vital capacity (FVC), forced expiratory volume during the first second (FEV1.0), and peak expiratory flow (PEF)] alongside a graded maximal aerobic exercise test (GXT). After 4 weeks of moderate-intensity aerobic excise with their assigned breathing condition, variables were reassessed at visit 2 (V2, post-study). Pulmonary function was assessed via spirometry, and respiratory parameters were assessed via a metabolic cart. Ultrasound sonography was utilized to assess peak-systolic (PSV) and end-diastolic velocity (EDV) of the internal (ICA) and external (ECA) carotid artery. Multivariate models and mixed between-within repeated measures ANOVAs with Bonferroni corrections were utilized to analyze all data with a significance set at p < 0.05. Results: During the V2 GXT, the ICA PSV was significantly higher (p = 0.023) in the NB (71.05 ± 3.70 cm/s) group than the CB (56.00 ± 3.71 cm/s) group at 100% of VO2max. Similarly, the ICA EDV was significantly higher (p = 0.017) in the NB (17.69 ± 1.49 cm/s) group than the CB (11.30 ± 1.50 cm/s) group at 100% of VO2max. From V1 to V2, the NB group (p = 0.033) significantly improved FEV1.0 (V1: 4.33 ± 0.64 L; V2: 4.47 ± 0.67 L), while the CB group (p = 0.038) improved PEF (V1: 543.55 ± 96.41 L·min-1; V2: 588.77 ± 66.86 L·min-1). Conclusion: After 4 weeks of moderate-intensity aerobic exercise utilizing NB, our results suggest that the primary cerebrovascular adaptation achieved was related to a reduction in cerebrovascular resistance. Additionally, aerobic exercise training with NB displayed signs of greater alveolar elasticity."],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["https://hdl.handle.net/2104/13105"],"dc:language.iso":["en"],"dc:rights":["Baylor University works are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission."],"dc:subject":["Oxygen uptake.","Hypoventilation.","Hyperemia.","Partial pressure of end‑tidal CO2 (PetCO2)","Airway resistance.","Cognition."],"dc:title":["Cerebrovascular and respiratory adaptations following 4 weeks of transient hypercapnic aerobic exercise."],"dc:type":["Thesis"],"thesis:degree_level":["Doctoral"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["Baylor University."]},"updated_at":"2026-07-24T01:07:56Z"}