The effect of hypoxia on the cytotoxicity of diesel exhaust particles and a novel oxygenating therapeutic in four cell lines.

Hypoxia is characterized by oxygen levels in tissue below 2% and is implicated in many diseases and adverse health outcomes including chronic lung disease, neurodegenerative diseases, and delayed wound-healing. Many solutions for tackling hypoxia to alleviate such conditions have been proposed but all carry significant limitations. This study attempts to characterize a novel oxygenating therapeutic known as Ox66™. Another major human health concern is diesel exhaust particles (DEP), a prominent component of air pollution. This study evaluates the toxicity of DEP, Ox66™, and a mixture of both during both hypoxia and normoxia and in 24- and 48-hour exposures using four cell lines. The effect of hypoxia on cytotoxicity carries implications for the health risk assessment of air pollution in patients suffering from hypoxia-related diseases. Additionally, the effect of Ox66™ on the hypoxia induced changes in DEP exposures as observed in their mixture may provide clues about its efficacy.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Masters

Grantor

Baylor University.

Year dc:date.issued

2020

Author dc:creator

• Dabi, Amjad, 1990-

Advisor dc:contributor.advisor

• Bruce, Erica Dawn.

• Hypoxia.
• Cytotoxicity.
• Diesel exhaust particles.

Statement dc:rights

• Baylor University works are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.

Language dc:language.iso

en

Handle dc:identifier.uri

https://hdl.handle.net/2104/11097

OAI identifier oai:identifier

oai:baylor-ir.tdl.org:2104/11097