A vitamin D enriched diet attenuates sex-specific behavioral deficits in the NS-Pten knockout mouse.

Individuals who experience recurrent spontaneous seizures are at a high risk for bone fractures as well as an increased likelihood of a comorbid diagnosis of Autism spectrum disorder. Additionally, individuals with epilepsy could have vitamin D deficiencies. The neural subset-specific (NS) Pten knockout (KO) mouse has shown autistic-like deficits and has a lower bone mineral density. We examined the effect of a vitamin D enriched diet in the NS-Pten KO mouse. Results indicated that a vitamin D diet attenuated altered activity levels in male NS-Pten KO mice. NS-Pten KO animals exhibited a reduction in sociability, however in male wildtype mice, vitamin D increased sociability. There was a significant effect of genotype and death, and between diet and death, finding that only CTL NS-Pten KO animals died. Overall, these findings suggest that a vitamin D enriched diet had a significant impact on the behavioral phenotype and survivability of NS-Pten KO mice.

Name thesis:degree_name

M.A.

Level thesis:degree_level

Masters

Grantor

Baylor University.

Year dc:date.issued

2020

Author dc:creator

• Womble, Paige Deann, 1995-

Advisor dc:contributor.advisor

• Lugo, Joaquin N.

• Epilepsy.
• Autism spectrum disorder (ASD)
• Bone density.
• Seizures.
• Fortified diet.

Statement dc:rights

• Baylor University works are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.

Language dc:language.iso

en

Handle dc:identifier.uri

https://hdl.handle.net/2104/11095

OAI identifier oai:identifier

oai:baylor-ir.tdl.org:2104/11095