Cardiovascular and renal responses to continuous, moderate and high-intensity interval exercise in mid-spectrum CKD.

The purpose of the present investigation was to determine the effect a short acute bout of aerobic exercise had on vascular and renal function in individuals with midspectrum CKD. Six men and fourteen women (Age = 62.0 ± 10 years; BMI = 37.3 ± 8.3; Waist = 98.9 ± 12.7; VO2max = 19.4 ± 4.6; and eGFR = 51.5 ± 6.5) participated in two experimental conditions: high-intensity interval exercise (HIIE) and continuous moderate-intensity exercise (CMIE). Each exercise condition lasted for 30 minutes and was completed after an 8- to 12-hour fast. Ultrasound-determined flow-mediated dilation of the brachial artery (FMD) was assessed before, 1 and 24 hrs after exercise. Blood and urine samples were taken before, 1 and 24 hrs post-exercise. Serum and plasma samples were measured for nitrotyrosine (ᶟ¯NT) asymmetric dimethyl arginine (ADMA), paroxonase-1 (PON-1), total antioxidant capacity (TAC), and creatinine. Urine samples were measured for epidermal growth factor (uEGF) and creatinine and the uEGF/uCr ratio was calculated as a marker of renal function. MDRD and CKD-EPI estimates of glomerular filtration rates were calculated. All samples were analyzed using 2-way repeated-measures ANOVA. Comparison-wise significance was established at p < 0.05. FMD was increased similarly with HIIE and CMIE. FMD increased 4.4% ± 1.4 at 1 hour and 2.9% ± 0.9 at 24 hour post-exercise (p < 0.005). ADMA was decreased 5.9% ± 2.3 by 24 hours after exercise (p < 0.0006), while PON-1 increased 4.6% ± 4.9 (p < 0.0097) and TAC 4.3% ± 4.2 (p < 0.012), reaching their zenith 24 hours post-exercise. Serum creatine decreased by 11% ± 3.2 at 1 and 24 hours after exercise (p < 0.0061) while eGFR increased 1 hour post-exercise and returned to baseline by 24 hours. uEGF/uCr ratio remained unaltered in both exercise conditions; however, eGFR equations MDRD increased by 16.6% ± 4.6 and CKD-EPI increased by 18.9% ± 4.5 were greatest after exercise (MDRD = p < 0.0096 and CKDEPI = p < 0.007). Exercise improves measures of vascular and renal function in mid-spectrum CKD. Results were similar after HIIE and CMIE and may last for several hours after exercise. Therefore, a single episode of HIIE or CMIE transiently improves cardiovascular health in individuals with mid-spectrum CKD.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Doctoral

Grantor

Baylor University.

Year dc:date.issued

2018

Author dc:creator

• Forsse, Jeff Stephen, 1986-

Advisor dc:contributor.advisor

• Grandjean, Peter W.

• Vascular function.
• Renal function.
• Endothelial function.
• High intensity interval exercise.
• Continuous moderate-intensity exercise.
• Chronic kidney disease.

Statement dc:rights

• Baylor University works are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.

Language dc:language.iso

en

Handle dc:identifier.uri

https://hdl.handle.net/2104/10512

OAI identifier oai:identifier

oai:baylor-ir.tdl.org:2104/10512