Dermal delivery of Centella asiatica using hyaluronic acid niosomal system for wound healing
type: CreativeWork
description: Background and aims: The human skin is the primary barrier that protects internal tissues from mechanical injury, infection, extreme heat and is crucial for haemostasias. The skin is vulnerable to injury, which has many consequences for both individual patients and the healthcare economy. Skin injuries and wounds should eventually heal normally through the natural process of skin cell restoration. However, significant clinical challenges act as an obstacle for time-controlled clean wound healing. Asiaticoside (ASC) and asiatic acid (AA) are natural bioactive compounds from Centella asiatica. Many effects of these two compounds, including promoting fibroblast proliferation, increased epithelial cell migration, and new capillary formation, has been reported. Their efficacy has been demonstrated in in vitro and in vivo studies. However, these compounds are fragile and need to be protected from degradation. Taken together, it would be advantageous if the compounds were encapsulated, which would shield them from the external environment and also facilitate sustained release, enhancing their therapeutic effects. In addition, enriching a biocompatible hydrogel with drug-loaded niosomes will allow easy application, and the beneficial effects of the hydrogel will also enhance healing. Objective: The aim of this project was to develop a niosome loaded hydrogel system to deliver bioactive compounds to skin wounds to accelerate wound healing. The drug candidates are two compounds from Centella asiatica, namely, asiaticoside (ASC) and asiatic acid (AA). Methods: A high-performance liquid chromatography (HPLC) method was developed and validated to simultaneously quantify the two compounds; preformulation studies were performed to study their physicochemical properties. ASC-loaded and AA-loaded niosomes were prepared using film hydration method and the Design of Experiment strategy was applied to optimise the formulations. Optimised niosomes were coated with hyaluronic acid and su…
abstract: Background and aims: The human skin is the primary barrier that protects internal tissues from mechanical injury, infection, extreme heat and is crucial for haemostasias. The skin is vulnerable to injury, which has many consequences for both individual patients and the healthcare economy. Skin injuries and wounds should eventually heal normally through the natural process of skin cell restoration. However, significant clinical challenges act as an obstacle for time-controlled clean wound healing. Asiaticoside (ASC) and asiatic acid (AA) are natural bioactive compounds from Centella asiatica. Many effects of these two compounds, including promoting fibroblast proliferation, increased epithelial cell migration, and new capillary formation, has been reported. Their efficacy has been demonstrated in in vitro and in vivo studies. However, these compounds are fragile and need to be protected from degradation. Taken together, it would be advantageous if the compounds were encapsulated, which would shield them from the external environment and also facilitate sustained release, enhancing their therapeutic effects. In addition, enriching a biocompatible hydrogel with drug-loaded niosomes will allow easy application, and the beneficial effects of the hydrogel will also enhance healing. Objective: The aim of this project was to develop a niosome loaded hydrogel system to deliver bioactive compounds to skin wounds to accelerate wound healing. The drug candidates are two compounds from Centella asiatica, namely, asiaticoside (ASC) and asiatic acid (AA). Methods: A high-performance liquid chromatography (HPLC) method was developed and validated to simultaneously quantify the two compounds; preformulation studies were performed to study their physicochemical properties. ASC-loaded and AA-loaded niosomes were prepared using film hydration method and the Design of Experiment strategy was applied to optimise the formulations. Optimised niosomes were coated with hyaluronic acid and su…
author: Chen, Shuo
license: https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
date published: 2022
date modified: 2026-07-24T01:03:56Z
provider: University of Auckland
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: ResearchSpace@Auckland

PropertyValue
property ID: Handle
value: https://hdl.handle.net/2292/62746