RoSE Enhancement for In Vitro Simulations of Human Swallowing
type: CreativeWork
description: Dysphagia or trouble swallowing is a prevalent medical condition among the elderly, individuals with esophageal strictures, and persons on long-term pill medication, with patient age, different pathologies, and solid dosage product characteristics (e.g., size, shape, and composition) contributing to the cause. All the in-vitro studies aiming to improve the therapeutic interventions in dysphagia lack the technologies to associate the effects of the dynamic forces involved in the esophageal peristalsis. The RoSE (Robotic Soft Esophagus) addresses this gap by combining the fields of material sciences, actuation, and control technologies. The RoSE is an open loop, pneumatically controlled, compliant, and continuous soft robotic actuator designed to mimic peristalsis. Many attributes of the esophagus, such as conduit length, diameter, peristalsis velocity, and conduit wall activation, are replicated in RoSE. Still, it lacks embedded sensors mimicking the mechanoreceptors in an esophageal lumen. Exploring the opportunities in improving the RoSE as an analytical tool for in-vitro swallowing studies has been the focus of this research. The components of this research were the following: 1) Design and characterize soft stretchable carbon black sensors and their modeling for sensor-actuator calibration and control, 2) Developing fluid-structure interaction simulation model to learn the parameter variations in bolus transit which are unknown due to lack of sensors, 3) Develop clinically relevant protocols and conduct in-vitro swallow studies for stent migration and solid dosage medication transit analysis. Many of the existing sensors technologies suffer the drawbacks such as robot occlusion, interference, or difficulties in surface compatibility. Designing soft stretchable sensing devices compatible with the soft robot and designing robust controllers are challenging problems in and of themselves. Carbon-based nanomaterials embedded in elastomers are cost-effective choices in…
abstract: Dysphagia or trouble swallowing is a prevalent medical condition among the elderly, individuals with esophageal strictures, and persons on long-term pill medication, with patient age, different pathologies, and solid dosage product characteristics (e.g., size, shape, and composition) contributing to the cause. All the in-vitro studies aiming to improve the therapeutic interventions in dysphagia lack the technologies to associate the effects of the dynamic forces involved in the esophageal peristalsis. The RoSE (Robotic Soft Esophagus) addresses this gap by combining the fields of material sciences, actuation, and control technologies. The RoSE is an open loop, pneumatically controlled, compliant, and continuous soft robotic actuator designed to mimic peristalsis. Many attributes of the esophagus, such as conduit length, diameter, peristalsis velocity, and conduit wall activation, are replicated in RoSE. Still, it lacks embedded sensors mimicking the mechanoreceptors in an esophageal lumen. Exploring the opportunities in improving the RoSE as an analytical tool for in-vitro swallowing studies has been the focus of this research. The components of this research were the following: 1) Design and characterize soft stretchable carbon black sensors and their modeling for sensor-actuator calibration and control, 2) Developing fluid-structure interaction simulation model to learn the parameter variations in bolus transit which are unknown due to lack of sensors, 3) Develop clinically relevant protocols and conduct in-vitro swallow studies for stent migration and solid dosage medication transit analysis. Many of the existing sensors technologies suffer the drawbacks such as robot occlusion, interference, or difficulties in surface compatibility. Designing soft stretchable sensing devices compatible with the soft robot and designing robust controllers are challenging problems in and of themselves. Carbon-based nanomaterials embedded in elastomers are cost-effective choices in…
author: Ali, Sherine Jesna Valiyaveetil
license: https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
date published: 2021
date modified: 2026-07-24T01:05:30Z
provider: University of Auckland
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: ResearchSpace@Auckland

PropertyValue
property ID: Handle
value: https://hdl.handle.net/2292/59544