Cortical thinning and neuropsychological changes in presymptomatic Huntington's Disease
type: CreativeWork
description: Degeneration of the striatum and striatal-frontal circuits are generally thought to cause most of the neuropsychological symptoms experienced in Huntington‘s Disease (HD). Advances in cortical thickness mapping (an automated MRI method for precisely measuring the cortical thickness across the entire cortex) provide a new technique for examining changes in the brain in HD. Recent studies using this technology have reported provocative results. They found significant cortical thinning in participants with early HD (Rosas et al., 2002; Rosas et al., 2008) and even in presymptomatic HD (Rosas et al., 2005). Moreover, cortical thinning was most prominent in posterior regions of the brain, with relative preservation of the anterior frontal regions. The present study replicated Rosas et al.‘s (2005) study but used a larger sample of presymptomatic HD participants (n = 19) and a control group matched for age, gender and education (n = 19). Presymptomatic HD participants were divided into two groups, PreHDclose and PreHDfar, based on their estimated proximity to clinical onset. The distribution of cortical thinning was assessed using an identical MRI method to previous cortical thinning studies with HD participants. Specific neuropsychological tests were used to assess cognitive and mood changes that may be associated with cortical thinning. It was hypothesised that cortical thinning would be more evident in posterior than frontal cortical regions. It was also hypothesised that presymptomatic HD participants would perform more poorly than controls on tests that are subserved primarily by specific posterior cortical regions, but not on tests that are subserved by anterior cortical regions. Lastly, it was predicted that poorer performance in the neuropsychological measures would be associated with greater thinning in cortical regions that are important during performance of these tasks. Consistent with predictions, the presymptomatic HD group showed regionally-specific cortica…
abstract: Degeneration of the striatum and striatal-frontal circuits are generally thought to cause most of the neuropsychological symptoms experienced in Huntington‘s Disease (HD). Advances in cortical thickness mapping (an automated MRI method for precisely measuring the cortical thickness across the entire cortex) provide a new technique for examining changes in the brain in HD. Recent studies using this technology have reported provocative results. They found significant cortical thinning in participants with early HD (Rosas et al., 2002; Rosas et al., 2008) and even in presymptomatic HD (Rosas et al., 2005). Moreover, cortical thinning was most prominent in posterior regions of the brain, with relative preservation of the anterior frontal regions. The present study replicated Rosas et al.‘s (2005) study but used a larger sample of presymptomatic HD participants (n = 19) and a control group matched for age, gender and education (n = 19). Presymptomatic HD participants were divided into two groups, PreHDclose and PreHDfar, based on their estimated proximity to clinical onset. The distribution of cortical thinning was assessed using an identical MRI method to previous cortical thinning studies with HD participants. Specific neuropsychological tests were used to assess cognitive and mood changes that may be associated with cortical thinning. It was hypothesised that cortical thinning would be more evident in posterior than frontal cortical regions. It was also hypothesised that presymptomatic HD participants would perform more poorly than controls on tests that are subserved primarily by specific posterior cortical regions, but not on tests that are subserved by anterior cortical regions. Lastly, it was predicted that poorer performance in the neuropsychological measures would be associated with greater thinning in cortical regions that are important during performance of these tasks. Consistent with predictions, the presymptomatic HD group showed regionally-specific cortica…
author: Davison, John W.
language: en
keywords: Cortex, Neuropsychology, Huntington's disease, Cognitive, Cognition, HD, Dementia, MRI
license: https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
date published: 2009
date modified: 2026-07-24T01:03:37Z
provider: University of Auckland
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: ResearchSpace@Auckland

PropertyValue
property ID: Handle
value: https://hdl.handle.net/2292/4955