Intense Pulsed Light for the Treatment of Evaporative Dry Eye
type: CreativeWork
description: Background Meibomian gland dysfunction (MGD) is a major aetiological factor in the development of evaporative dry eye (EDE), a common presentation in ophthalmic clinics which causes significant detrimental effects on quality of life. Traditional management strategies often fail to provide sustainable solutions, prompting patients and clinicians to seek alternative options. One novel treatment to emerge in recent years is intense pulsed light (IPL). Several, largely retrospective or open-label, studies have demonstrated an improvement in the signs and symptoms of EDE after periocular application, but possible mechanism(s) of action of IPL in the context of long-term MGD management remain poorly understood. Purpose To explore the dry eye practices of New Zealand eyecare professionals against current evidencebased guidelines, then utilise contemporary diagnostic metrics to evaluate the therapeutic potential of periocular IPL application as a treatment for MGD and the potential mechanism(s) of action. Methods Eighty-seven subjects with mild to moderate MGD were enrolled in a prospective, randomised, double-masked, non-paired eye, placebo-controlled study. Participants randomised to receive a course of four IPL treatments or four sham treatments (control), were evaluated at baseline, prior to treatment on Day 15, Day 45, Day 75 and as a follow-up only on Day 105 using: 1) validated dry eye questionnaires, 2) clinical diagnostic techniques, 3) non-contact aesthesiometry, 4) RNA expression of neuroinflammatory biomarkers, 5) tear film lipidomics, 6) in vivo confocal microscopy and 7) lid margin microflora assessments. Results A total of 30 participants (70% female, mean ± SD age of 55 ± 14) were randomised to the placebo arm of the study, and 56 participants were randomised to the treatment arm with 4 IPL flashes (n = 28, 68% female, mean ± SD age of 48 ± 15) or 5 IPL flashes (n = 29, 62% female, mean ± SD age of 56 ± 17) applied to the inferior periocular zone. Following …
abstract: Background Meibomian gland dysfunction (MGD) is a major aetiological factor in the development of evaporative dry eye (EDE), a common presentation in ophthalmic clinics which causes significant detrimental effects on quality of life. Traditional management strategies often fail to provide sustainable solutions, prompting patients and clinicians to seek alternative options. One novel treatment to emerge in recent years is intense pulsed light (IPL). Several, largely retrospective or open-label, studies have demonstrated an improvement in the signs and symptoms of EDE after periocular application, but possible mechanism(s) of action of IPL in the context of long-term MGD management remain poorly understood. Purpose To explore the dry eye practices of New Zealand eyecare professionals against current evidencebased guidelines, then utilise contemporary diagnostic metrics to evaluate the therapeutic potential of periocular IPL application as a treatment for MGD and the potential mechanism(s) of action. Methods Eighty-seven subjects with mild to moderate MGD were enrolled in a prospective, randomised, double-masked, non-paired eye, placebo-controlled study. Participants randomised to receive a course of four IPL treatments or four sham treatments (control), were evaluated at baseline, prior to treatment on Day 15, Day 45, Day 75 and as a follow-up only on Day 105 using: 1) validated dry eye questionnaires, 2) clinical diagnostic techniques, 3) non-contact aesthesiometry, 4) RNA expression of neuroinflammatory biomarkers, 5) tear film lipidomics, 6) in vivo confocal microscopy and 7) lid margin microflora assessments. Results A total of 30 participants (70% female, mean ± SD age of 55 ± 14) were randomised to the placebo arm of the study, and 56 participants were randomised to the treatment arm with 4 IPL flashes (n = 28, 68% female, mean ± SD age of 48 ± 15) or 5 IPL flashes (n = 29, 62% female, mean ± SD age of 56 ± 17) applied to the inferior periocular zone. Following …
author: Xue, Linyue
license: https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
date published: 2019
date modified: 2026-07-24T01:03:37Z
provider: University of Auckland
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: ResearchSpace@Auckland

PropertyValue
property ID: Handle
value: https://hdl.handle.net/2292/48654