Microarray-based gene set analysis in cancer studies

This work addresses the development and application of gene set analysis methods to problems in microarray-based data sets. The work consists of three parts. In the first part a gene set analysis method (PCOT2) is developed. It utilizes inter-gene correlation to detect significant alteration in gene sets across experimental conditions. The second part is focused on the exploration of correlation-based gene sets in conjunction with the application of the PCOT2 testing method in the investigation of biological mechanisms underlying breast cancer recurrence. In the third part, statistical models for analyzing combined microarray-based expression and genomic copy number data are developed. In addition, an analysis which incorporates tumour subgroups is shown to provide more accurate prognosis assessment for breast cancer patients.

Name thesis:degree_name

PhD

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Statistics

Grantor dc:publisher

ResearchSpace@Auckland

Year dc:date.issued

2008

Author dc:creator

• Song, Qin Sarah

Advisor dc:contributor.advisor

• Dr. Michael Alan Black

• Statistics
• Bioinformatics

Statement dc:rights

• Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Licence dc:rights.uri

• https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm

Language dc:language.iso

en

Handle dc:identifier.uri

https://hdl.handle.net/2292/4239

OAI identifier oai:identifier

oai:researchspace.auckland.ac.nz:2292/4239