{"id":{"repo_id":"auckland-ms","oai_identifier":"oai:researchspace.auckland.ac.nz:2292/3313"},"canonical_url":"https://search.dev.ndltd.org/etd/auckland-ms/oai:researchspace.auckland.ac.nz:2292/3313","repository":{"repo_id":"auckland-ms","name":"University of Auckland","base_url":"https://researchspace.auckland.ac.nz/server/oai/request"},"display":{"title":"The Development and efficacy of cognitive behaviour therapy for multiple sclerosis fatigue: a randomised controlled trial","abstract":"Aim Multiple Sclerosis (MS) is an unpredictable demyelinating disease of the central nervous system (CNS), with fatigue being one of the least understood symptoms. Based on a systematic review of the literature, a cognitive behavioural model of MS fatigue was developed and used to design a manualised eight session cognitive behaviour therapy (CBT) intervention to treat MS fatigue. The purpose of the randomized controlled trial (RCT) was to investigate the efficacy of CBT compared to relaxation training (RT) to treat fatigue in MS. Methods Seventy-two patients with MS fatigue were randomly assigned to either eight sessions of CBT or eight sessions of RT, designed to control for therapist time and attention. Participants were assessed before and after treatment, and at three and six months follow-up. Primary outcomes included the Fatigue Questionnaire (FQ) and the Clinical Global Impression Scale (CGIS). Secondary outcomes included measures of fatigue related impairment, mood, stress, sleep problems and daytime sleepiness. Seventy of the 72 participants completed all therapy sessions and 69 participants completed all assessments. Results Analyses were carried out by intention-to-heat. There was a significant group by time interaction for fatigue, indicating that the CBT group had significantly greater reductions in fatigue severity than the RT group (p<.02). A-priori contrasts showed that this significant effect was largely accounted for by changes between baseline and end of treatment (P<.00). By six month follow-up improvement in fatigue was equivalent in both groups. The key mechanism of improvement in fatigue severity during CBT was a positive change in schematic beliefs about fatigue. At the end of treatment 88.6% of the CBT group rated themselves as improved compared to 73% of the RT group, but this difference was not significant (p<.09). Both groups improved on almost all secondary outcomes, with the CBT participants improving more significantly on depression, anxiety and stress between baseline and end of treatment (p<.05). Conclusions CBT appears to be an effective treatment for MS fatigue, with CBT participants improving significantly more on fatigue than RT participants between baseline and end of treatment. Obtained effect sizes for fatigue in both CBT and RT were considerably larger than those in previous controlled trials of pharmacological and non-pharmacological interventions. Both groups improved on almost all of the secondary outcomes. Findings support the relevance of a cognitive behavioural model for MS fatigue.","abstract_html":"Aim Multiple Sclerosis (MS) is an unpredictable demyelinating disease of the central nervous system (CNS), with fatigue being one of the least understood symptoms. Based on a systematic review of the literature, a cognitive behavioural model of MS fatigue was developed and used to design a manualised eight session cognitive behaviour therapy (CBT) intervention to treat MS fatigue. The purpose of the randomized controlled trial (RCT) was to investigate the efficacy of CBT compared to relaxation training (RT) to treat fatigue in MS. Methods Seventy-two patients with MS fatigue were randomly assigned to either eight sessions of CBT or eight sessions of RT, designed to control for therapist time and attention. Participants were assessed before and after treatment, and at three and six months follow-up. Primary outcomes included the Fatigue Questionnaire (FQ) and the Clinical Global Impression Scale (CGIS). Secondary outcomes included measures of fatigue related impairment, mood, stress, sleep problems and daytime sleepiness. Seventy of the 72 participants completed all therapy sessions and 69 participants completed all assessments. Results Analyses were carried out by intention-to-heat. There was a significant group by time interaction for fatigue, indicating that the CBT group had significantly greater reductions in fatigue severity than the RT group (p&lt;.02). A-priori contrasts showed that this significant effect was largely accounted for by changes between baseline and end of treatment (P&lt;.00). By six month follow-up improvement in fatigue was equivalent in both groups. The key mechanism of improvement in fatigue severity during CBT was a positive change in schematic beliefs about fatigue. At the end of treatment 88.6% of the CBT group rated themselves as improved compared to 73% of the RT group, but this difference was not significant (p&lt;.09). Both groups improved on almost all secondary outcomes, with the CBT participants improving more significantly on depression, anxiety and stress between baseline and end of treatment (p&lt;.05). Conclusions CBT appears to be an effective treatment for MS fatigue, with CBT participants improving significantly more on fatigue than RT participants between baseline and end of treatment. Obtained effect sizes for fatigue in both CBT and RT were considerably larger than those in previous controlled trials of pharmacological and non-pharmacological interventions. Both groups improved on almost all of the secondary outcomes. Findings support the relevance of a cognitive behavioural model for MS fatigue.","abstract_has_math":false,"creators":["Van Kessel, Kirsten"],"institution":"ResearchSpace@Auckland","degree_name":"PhD","degree_level":"Doctoral","degree_discipline":"Health Psychology","degree_department":null,"school":null,"contributors":[],"advisors":["Dr Rona Moss-Morris","Dr Ernie Willoughby"],"committee_chairs":[],"committee_members":[],"year":2007,"date_issued":"2007","date_published":"2007","updated_at":"2026-07-24T01:03:18Z","subjects":[],"languages":["en"],"rights":["Whole document restricted but available by request. Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated."],"rights_urls":["https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm"],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2292/3313","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Dr Rona Moss-Morris","Dr Ernie Willoughby"]},{"key":"dc:creator","label":"Author","values":["Van Kessel, Kirsten"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2009-01-11T21:10:15Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2009-01-11T21:10:15Z"]},{"key":"dc:date.issued","label":"Date","values":["2007"]},{"key":"dc:publisher","label":"Institution","values":["ResearchSpace@Auckland"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["UoA1729273"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Health Psychology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["PhD"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["The University of Auckland"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Whole document restricted but available by request. Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated."]},{"key":"dc:rights.uri","label":"Rights URI","values":["https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/2292/3313"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Whole document restricted, but available by request, use the feedback form to request access."]},{"key":"dc:description.abstract","label":"Abstract","values":["Aim Multiple Sclerosis (MS) is an unpredictable demyelinating disease of the central nervous system (CNS), with fatigue being one of the least understood symptoms. Based on a systematic review of the literature, a cognitive behavioural model of MS fatigue was developed and used to design a manualised eight session cognitive behaviour therapy (CBT) intervention to treat MS fatigue. The purpose of the randomized controlled trial (RCT) was to investigate the efficacy of CBT compared to relaxation training (RT) to treat fatigue in MS. Methods Seventy-two patients with MS fatigue were randomly assigned to either eight sessions of CBT or eight sessions of RT, designed to control for therapist time and attention. Participants were assessed before and after treatment, and at three and six months follow-up. Primary outcomes included the Fatigue Questionnaire (FQ) and the Clinical Global Impression Scale (CGIS). Secondary outcomes included measures of fatigue related impairment, mood, stress, sleep problems and daytime sleepiness. Seventy of the 72 participants completed all therapy sessions and 69 participants completed all assessments. Results Analyses were carried out by intention-to-heat. There was a significant group by time interaction for fatigue, indicating that the CBT group had significantly greater reductions in fatigue severity than the RT group (p<.02). A-priori contrasts showed that this significant effect was largely accounted for by changes between baseline and end of treatment (P<.00). By six month follow-up improvement in fatigue was equivalent in both groups. The key mechanism of improvement in fatigue severity during CBT was a positive change in schematic beliefs about fatigue. At the end of treatment 88.6% of the CBT group rated themselves as improved compared to 73% of the RT group, but this difference was not significant (p<.09). Both groups improved on almost all secondary outcomes, with the CBT participants improving more significantly on depression, anxiety and stress between baseline and end of treatment (p<.05). Conclusions CBT appears to be an effective treatment for MS fatigue, with CBT participants improving significantly more on fatigue than RT participants between baseline and end of treatment. Obtained effect sizes for fatigue in both CBT and RT were considerably larger than those in previous controlled trials of pharmacological and non-pharmacological interventions. Both groups improved on almost all of the secondary outcomes. Findings support the relevance of a cognitive behavioural model for MS fatigue."]},{"key":"dc:format","label":"Dc Format","values":["Scanned from print thesis"]},{"key":"dc:title","label":"Title","values":["The Development and efficacy of cognitive behaviour therapy for multiple sclerosis fatigue: a randomised controlled trial"]}]}],"canonical_facts":{"dc:contributor.advisor":["Dr Rona Moss-Morris","Dr Ernie Willoughby"],"dc:creator":["Van Kessel, Kirsten"],"dc:date.accessioned":["2009-01-11T21:10:15Z"],"dc:date.available":["2009-01-11T21:10:15Z"],"dc:date.issued":["2007"],"dc:description":["Whole document restricted, but available by request, use the feedback form to request access."],"dc:description.abstract":["Aim Multiple Sclerosis (MS) is an unpredictable demyelinating disease of the central nervous system (CNS), with fatigue being one of the least understood symptoms. Based on a systematic review of the literature, a cognitive behavioural model of MS fatigue was developed and used to design a manualised eight session cognitive behaviour therapy (CBT) intervention to treat MS fatigue. The purpose of the randomized controlled trial (RCT) was to investigate the efficacy of CBT compared to relaxation training (RT) to treat fatigue in MS. Methods Seventy-two patients with MS fatigue were randomly assigned to either eight sessions of CBT or eight sessions of RT, designed to control for therapist time and attention. Participants were assessed before and after treatment, and at three and six months follow-up. Primary outcomes included the Fatigue Questionnaire (FQ) and the Clinical Global Impression Scale (CGIS). Secondary outcomes included measures of fatigue related impairment, mood, stress, sleep problems and daytime sleepiness. Seventy of the 72 participants completed all therapy sessions and 69 participants completed all assessments. Results Analyses were carried out by intention-to-heat. There was a significant group by time interaction for fatigue, indicating that the CBT group had significantly greater reductions in fatigue severity than the RT group (p<.02). A-priori contrasts showed that this significant effect was largely accounted for by changes between baseline and end of treatment (P<.00). By six month follow-up improvement in fatigue was equivalent in both groups. The key mechanism of improvement in fatigue severity during CBT was a positive change in schematic beliefs about fatigue. At the end of treatment 88.6% of the CBT group rated themselves as improved compared to 73% of the RT group, but this difference was not significant (p<.09). Both groups improved on almost all secondary outcomes, with the CBT participants improving more significantly on depression, anxiety and stress between baseline and end of treatment (p<.05). Conclusions CBT appears to be an effective treatment for MS fatigue, with CBT participants improving significantly more on fatigue than RT participants between baseline and end of treatment. Obtained effect sizes for fatigue in both CBT and RT were considerably larger than those in previous controlled trials of pharmacological and non-pharmacological interventions. Both groups improved on almost all of the secondary outcomes. Findings support the relevance of a cognitive behavioural model for MS fatigue."],"dc:format":["Scanned from print thesis"],"dc:identifier.uri":["https://hdl.handle.net/2292/3313"],"dc:language.iso":["en"],"dc:publisher":["ResearchSpace@Auckland"],"dc:relation.isreferencedby":["UoA1729273"],"dc:rights":["Whole document restricted but available by request. Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated."],"dc:rights.uri":["https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm"],"dc:title":["The Development and efficacy of cognitive behaviour therapy for multiple sclerosis fatigue: a randomised controlled trial"],"dc:type":["Thesis"],"thesis:degree_discipline":["Health Psychology"],"thesis:degree_level":["Doctoral"],"thesis:degree_name":["PhD"],"thesis:institution_name":["The University of Auckland"]},"updated_at":"2026-07-24T01:03:18Z"}