Tetrahydrobiopterin metabolism
type: CreativeWork
description: A technique for the measurement of biopterin using HPLC has been developed and compared against the established Crithidia fasciculata assay. The two assays give a similar reading when samples are unoxidised but after acid/iodine oxidation Crithidia reads higher, probably due to the presence of other pterins. Using HPLC as a measuring technique an oral dose of phenylalanine has been found to elevate the level of biopterin derivatives in the blood whilst tyrosine had no effect...
abstract: A technique for the measurement of biopterin using HPLC has been developed and compared against the established Crithidia fasciculata assay. The two assays give a similar reading when samples are unoxidised but after acid/iodine oxidation Crithidia reads higher, probably due to the presence of other pterins. Using HPLC as a measuring technique an oral dose of phenylalanine has been found to elevate the level of biopterin derivatives in the blood whilst tyrosine had no effect...
author: Hamon, Christopher G.B.
date published: 1984
date modified: 2026-07-24T01:01:35Z
provider: Aston University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Aston University

PropertyValue
property ID: DOI
value: 10.48780/publications.aston.ac.uk.00011757