{"id":{"repo_id":"aston","oai_identifier":"oai:publications.aston.ac.uk:11757"},"canonical_url":"https://search.dev.ndltd.org/etd/aston/oai:publications.aston.ac.uk:11757","repository":{"repo_id":"aston","name":"Aston University","base_url":"https://publications.aston.ac.uk/cgi/oai2"},"display":{"title":"Tetrahydrobiopterin metabolism","abstract":"A technique for the measurement of biopterin using HPLC has been developed and compared against the established Crithidia fasciculata assay. The two assays give a similar reading when samples are unoxidised but after acid/iodine oxidation Crithidia reads higher, probably due to the presence of other pterins. Using HPLC as a measuring technique an oral dose of phenylalanine has been found to elevate the level of biopterin derivatives in the blood whilst tyrosine had no effect...","abstract_html":"A technique for the measurement of biopterin using HPLC has been developed and compared against the established Crithidia fasciculata assay. The two assays give a similar reading when samples are unoxidised but after acid/iodine oxidation Crithidia reads higher, probably due to the presence of other pterins. Using HPLC as a measuring technique an oral dose of phenylalanine has been found to elevate the level of biopterin derivatives in the blood whilst tyrosine had no effect...","abstract_has_math":false,"creators":["Hamon, Christopher G.B."],"institution":"Aston University","degree_name":"Ph.D.","degree_level":"doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1984,"date_issued":"1984","date_published":"1984","updated_at":"2026-07-24T01:01:35Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://doi.org/10.48780/publications.aston.ac.uk.00011757","outbound_label":"DOI","outbound_source":"dc:identifier.doi"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Hamon, Christopher G.B."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1984"]},{"key":"dc:date.issued","label":"Date","values":["1984"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Chemical Engineering & Applied Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["Aston University"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://publications.aston.ac.uk/id/eprint/11757/"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Ph.D."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.doi","label":"DOI","values":["10.48780/publications.aston.ac.uk.00011757"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://publications.aston.ac.uk/id/eprint/11757/1/C.G.B._Hamon_1984_reduced.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["A technique for the measurement of biopterin using HPLC has been developed and compared against the established Crithidia fasciculata assay. The two assays give a similar reading when samples are unoxidised but after acid/iodine oxidation Crithidia reads higher, probably due to the presence of other pterins. Using HPLC as a measuring technique an oral dose of phenylalanine has been found to elevate the level of biopterin derivatives in the blood whilst tyrosine had no effect..."]},{"key":"dc:format","label":"Dc Format","values":["text"]},{"key":"dc:title","label":"Title","values":["Tetrahydrobiopterin metabolism"]}]}],"canonical_facts":{"dc:creator":["Hamon, Christopher G.B."],"dc:date":["1984"],"dc:date.issued":["1984"],"dc:description.abstract":["A technique for the measurement of biopterin using HPLC has been developed and compared against the established Crithidia fasciculata assay. The two assays give a similar reading when samples are unoxidised but after acid/iodine oxidation Crithidia reads higher, probably due to the presence of other pterins. 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