Substrate metabolism and acid secretion in the rat stomach
The aim of this work was, firstly, to identify which substrates could support acid secretion by rat parietal cells and secondly, to investigate the intracellular events involved in stimulus transduction in rat parietal cells. A technique was developed which enabled satisfactory measurements of arteriovenous differences across the rat stomach in vivo. Glucose, D-3-hydroxybutyrate and branched-chain amino acids were taken up by the stomach wall under control and acid-secreting (pentagastrin-stimulated) conditions. The pattern of substrate metabolism appeared unaffected by stimulation of acid secretion...
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