{"id":{"repo_id":"aston","oai_identifier":"oai:publications.aston.ac.uk:10116"},"canonical_url":"https://search.dev.ndltd.org/etd/aston/oai:publications.aston.ac.uk:10116","repository":{"repo_id":"aston","name":"Aston University","base_url":"https://publications.aston.ac.uk/cgi/oai2"},"display":{"title":"The Separation of Mixtures of Fatty Acid Derivatives by Continuous Chromatographic Refining","abstract":"A review is given of the factors affecting the performance and the scale up of chromatographic columns. The industrial separation of fatty acid derivatives and the application of G.L.C. as a possible separation method for fatty acids are also reviewed. The design and construction of a sequential continuous 5 chromatographic refiner (SCCR-2) for high temperature (up to 210°C) preparative scale G.L.C. separation is described. Counter-current operation was simulated by sequencing a system of inlet and outlet port functions around twelve fixed, 2.21 an diameter and 61 cm long stainless steel columns. The separation capabilities of the SCCR-2 unit have been investigated using mixtures of different fatty acid esters. The feed mixtures selected had separation factors in the range of 1.44- 2.8 and required equipment operation in the range of 105-210°C, while using OV-275 (a cynosilicone liquid phase) on Chromosorb P, as chromatographic packing material. Fatty acid derivatives; ethyl caprylate/ethyl caprate (separation factor (S.F.) 1.9, 105°C), ethyl caprate/ethyl laurate (S.F. 1.44, 160°C), ethyl laurate/methyl myristate (S.F. 1.54, 185°C) and methyl myristate/methyl stearate (S.F. 2.8, 206°C) were separated on the SCCR-2 unit. Purities of greater than 99% have been achieved for both product streams at feed rates of up to 80 an’ h ~ and at an operating, temperature of 105°C. Lower throughputs; 50, 25 and 20 am\"H ~ at operating temperatures 160, 185 and 205°C respectively were used to retain the purity in excess of 98.0% for both products. The experimental results of the separation of binary mixtures at different temperatures have been compared with the results of a plate model computation procedure. Results achieved from the theoretical study indicated partial agreement with the experimental findings.","abstract_html":"A review is given of the factors affecting the performance and the scale up of chromatographic columns. The industrial separation of fatty acid derivatives and the application of G.L.C. as a possible separation method for fatty acids are also reviewed. The design and construction of a sequential continuous 5 chromatographic refiner (SCCR-2) for high temperature (up to 210°C) preparative scale G.L.C. separation is described. Counter-current operation was simulated by sequencing a system of inlet and outlet port functions around twelve fixed, 2.21 an diameter and 61 cm long stainless steel columns. The separation capabilities of the SCCR-2 unit have been investigated using mixtures of different fatty acid esters. The feed mixtures selected had separation factors in the range of 1.44- 2.8 and required equipment operation in the range of 105-210°C, while using OV-275 (a cynosilicone liquid phase) on Chromosorb P, as chromatographic packing material. Fatty acid derivatives; ethyl caprylate/ethyl caprate (separation factor (S.F.) 1.9, 105°C), ethyl caprate/ethyl laurate (S.F. 1.44, 160°C), ethyl laurate/methyl myristate (S.F. 1.54, 185°C) and methyl myristate/methyl stearate (S.F. 2.8, 206°C) were separated on the SCCR-2 unit. Purities of greater than 99% have been achieved for both product streams at feed rates of up to 80 an’ h ~ and at an operating, temperature of 105°C. Lower throughputs; 50, 25 and 20 am"H ~ at operating temperatures 160, 185 and 205°C respectively were used to retain the purity in excess of 98.0% for both products. The experimental results of the separation of binary mixtures at different temperatures have been compared with the results of a plate model computation procedure. Results achieved from the theoretical study indicated partial agreement with the experimental findings.","abstract_has_math":false,"creators":["Howari, M.I."],"institution":"Aston University","degree_name":"Ph.D.","degree_level":"doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1980,"date_issued":"1980","date_published":"1980","updated_at":"2026-07-24T01:01:09Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Howari, M.I."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1980"]},{"key":"dc:date.issued","label":"Date","values":["1980"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Chemical Engineering & Applied Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["Aston University"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://publications.aston.ac.uk/id/eprint/10116/"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Ph.D."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://publications.aston.ac.uk/id/eprint/10116/1/264447_MI_Howari_1980.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["A review is given of the factors affecting the performance and the scale up of chromatographic columns. The industrial separation of fatty acid derivatives and the application of G.L.C. as a possible separation method for fatty acids are also reviewed. The design and construction of a sequential continuous 5 chromatographic refiner (SCCR-2) for high temperature (up to 210°C) preparative scale G.L.C. separation is described. Counter-current operation was simulated by sequencing a system of inlet and outlet port functions around twelve fixed, 2.21 an diameter and 61 cm long stainless steel columns. The separation capabilities of the SCCR-2 unit have been investigated using mixtures of different fatty acid esters. The feed mixtures selected had separation factors in the range of 1.44- 2.8 and required equipment operation in the range of 105-210°C, while using OV-275 (a cynosilicone liquid phase) on Chromosorb P, as chromatographic packing material. Fatty acid derivatives; ethyl caprylate/ethyl caprate (separation factor (S.F.) 1.9, 105°C), ethyl caprate/ethyl laurate (S.F. 1.44, 160°C), ethyl laurate/methyl myristate (S.F. 1.54, 185°C) and methyl myristate/methyl stearate (S.F. 2.8, 206°C) were separated on the SCCR-2 unit. Purities of greater than 99% have been achieved for both product streams at feed rates of up to 80 an’ h ~ and at an operating, temperature of 105°C. Lower throughputs; 50, 25 and 20 am\"H ~ at operating temperatures 160, 185 and 205°C respectively were used to retain the purity in excess of 98.0% for both products. The experimental results of the separation of binary mixtures at different temperatures have been compared with the results of a plate model computation procedure. Results achieved from the theoretical study indicated partial agreement with the experimental findings."]},{"key":"dc:format","label":"Dc Format","values":["text"]},{"key":"dc:title","label":"Title","values":["The Separation of Mixtures of Fatty Acid Derivatives by Continuous Chromatographic Refining"]}]}],"canonical_facts":{"dc:creator":["Howari, M.I."],"dc:date":["1980"],"dc:date.issued":["1980"],"dc:description.abstract":["A review is given of the factors affecting the performance and the scale up of chromatographic columns. The industrial separation of fatty acid derivatives and the application of G.L.C. as a possible separation method for fatty acids are also reviewed. The design and construction of a sequential continuous 5 chromatographic refiner (SCCR-2) for high temperature (up to 210°C) preparative scale G.L.C. separation is described. Counter-current operation was simulated by sequencing a system of inlet and outlet port functions around twelve fixed, 2.21 an diameter and 61 cm long stainless steel columns. The separation capabilities of the SCCR-2 unit have been investigated using mixtures of different fatty acid esters. The feed mixtures selected had separation factors in the range of 1.44- 2.8 and required equipment operation in the range of 105-210°C, while using OV-275 (a cynosilicone liquid phase) on Chromosorb P, as chromatographic packing material. Fatty acid derivatives; ethyl caprylate/ethyl caprate (separation factor (S.F.) 1.9, 105°C), ethyl caprate/ethyl laurate (S.F. 1.44, 160°C), ethyl laurate/methyl myristate (S.F. 1.54, 185°C) and methyl myristate/methyl stearate (S.F. 2.8, 206°C) were separated on the SCCR-2 unit. Purities of greater than 99% have been achieved for both product streams at feed rates of up to 80 an’ h ~ and at an operating, temperature of 105°C. Lower throughputs; 50, 25 and 20 am\"H ~ at operating temperatures 160, 185 and 205°C respectively were used to retain the purity in excess of 98.0% for both products. The experimental results of the separation of binary mixtures at different temperatures have been compared with the results of a plate model computation procedure. Results achieved from the theoretical study indicated partial agreement with the experimental findings."],"dc:format":["text"],"dc:identifier.uri":["https://publications.aston.ac.uk/id/eprint/10116/1/264447_MI_Howari_1980.pdf"],"dc:publisher.department":["Chemical Engineering & Applied Chemistry"],"dc:publisher.institution":["Aston University"],"dc:relation.isreferencedby":["https://publications.aston.ac.uk/id/eprint/10116/"],"dc:title":["The Separation of Mixtures of Fatty Acid Derivatives by Continuous Chromatographic Refining"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["doctoral"],"dc:type.qualificationname":["Ph.D."]},"updated_at":"2026-07-24T01:01:09Z"}