The use of nanotechnology in enhancing the efficacy of cosmetic actives of natural origin
type: CreativeWork
description: The trend towards natural cosmetics has had a strong and lasting impact on the cosmetics development. However, producing efficient and acceptable natural products presents a major technical challenge. The aim of this study was to investigate how adaptation of a new technology (nanotechnology) could influence the efficacy of natural actives in cosmetic products. The introductory part of this thesis presents a review of natural cosmetics in terms of their legal status and market share, including various attempts to define natural and/or organic cosmetics and comparisons of relevant certifications, as well as the merits of skin delivery systems in topical delivery. In this study, an ester form of Vitamin E, d-a-tocopheryl acetate (TA) , was chosen as a model natural active. Obtained from natural sources, vitamin E alcohol (tocopherol) has undergone esterification process in order to gain increased stability. This places it into the group of naturally derived actives, a subcategory of natural actives. A suitable, 'fit for purpose' analytical method for the assessment of TA was then developed and validated, employing high performance liquid chromatography (HPLC). The production of TA-Ioaded lipid nanocarriers (TA-LNC), with well-tolerated and in vivo biodegradable ingredients, has been achieved using the phase inversion method. High-speed centrifuging was established to be the most efficient purification method for LNC suspension. The size of lipid nanocarriers have been characterised by photon correlation spectroscopy (PCS) and by nanoparticle tracking analysis method (NTA). The TA-LNC have proven to be monodisperse, with the particle size of less than 60 nm and stable for at least 28 days in different temperatures (0 °C, 4°C and 28°C). The nanocarriers showed 57.7 ± 4.9% encapsulation efficiency of the original 110 mg of TA added. The recovery of TA from the purification method was found to be 90.4% ± 2.2. In the next stage, a suitable semi-solid dosage form was develo…
abstract: The trend towards natural cosmetics has had a strong and lasting impact on the cosmetics development. However, producing efficient and acceptable natural products presents a major technical challenge. The aim of this study was to investigate how adaptation of a new technology (nanotechnology) could influence the efficacy of natural actives in cosmetic products. The introductory part of this thesis presents a review of natural cosmetics in terms of their legal status and market share, including various attempts to define natural and/or organic cosmetics and comparisons of relevant certifications, as well as the merits of skin delivery systems in topical delivery. In this study, an ester form of Vitamin E, d-a-tocopheryl acetate (TA) , was chosen as a model natural active. Obtained from natural sources, vitamin E alcohol (tocopherol) has undergone esterification process in order to gain increased stability. This places it into the group of naturally derived actives, a subcategory of natural actives. A suitable, 'fit for purpose' analytical method for the assessment of TA was then developed and validated, employing high performance liquid chromatography (HPLC). The production of TA-Ioaded lipid nanocarriers (TA-LNC), with well-tolerated and in vivo biodegradable ingredients, has been achieved using the phase inversion method. High-speed centrifuging was established to be the most efficient purification method for LNC suspension. The size of lipid nanocarriers have been characterised by photon correlation spectroscopy (PCS) and by nanoparticle tracking analysis method (NTA). The TA-LNC have proven to be monodisperse, with the particle size of less than 60 nm and stable for at least 28 days in different temperatures (0 °C, 4°C and 28°C). The nanocarriers showed 57.7 ± 4.9% encapsulation efficiency of the original 110 mg of TA added. The recovery of TA from the purification method was found to be 90.4% ± 2.2. In the next stage, a suitable semi-solid dosage form was develo…
author: Moddaresi, Mojgan
language: en
keywords: Cosmetic Science
identifier: Moddaresi, Mojgan <https://ualresearchonline.arts.ac.uk/view/creators/Moddaresi=3AMojgan=3A=3A.html> (2019) The use of nanotechnology in enhancing the efficacy of cosmetic actives of natural origin. PhD thesis, University of the Arts London.
date published: 2019-05
date modified: 2026-07-24T01:00:43Z
provider: University of the Arts London
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of the Arts London