A chronically elevated vasopressin level has been associated with an impaired glucose regulation system in humans. A recent study in patients with diabetes suggested that low water intake is associated with impaired glucose regulation. The aim of this study was to examine the effect of hypertonic saline infusion on glucose regulation in healthy females. Thirty healthy, non-diabetic females performed a 2-h infusion followed by a 4-h oral glucose tolerance test (OGTT). Every subject participated in two trials separated by one month, in a counterbalanced order. Two trials were identical in the procedure, differing in the concentration of saline infusion, with one trial being 3% NaCl (HYPER), another being 0.9% NaCl (ISO). The HYPER trial led to an increase in plasma osmolality (time point 0 min, 305±0.91 vs. 287±0.61 mmol/kg, P
","abstract_html":"<p>A chronically elevated vasopressin level has been associated with an impaired glucose regulation system in humans. A recent study in patients with diabetes suggested that low water intake is associated with impaired glucose regulation. The aim of this study was to examine the effect of hypertonic saline infusion on glucose regulation in healthy females. Thirty healthy, non-diabetic females performed a 2-h infusion followed by a 4-h oral glucose tolerance test (OGTT). Every subject participated in two trials separated by one month, in a counterbalanced order. Two trials were identical in the procedure, differing in the concentration of saline infusion, with one trial being 3% NaCl (HYPER), another being 0.9% NaCl (ISO). The HYPER trial led to an increase in plasma osmolality (time point 0 min, 305±0.91 vs. 287±0.61 mmol/kg, P</p>","abstract_has_math":false,"creators":["Yang, Chunbo"],"institution":null,"degree_name":"Master of Science in Kinesiology (MS)","degree_level":"Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Ganio, Matthew S.","Washington, Tyrone A."],"advisors":["Kavouras, Stavros A."],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-05-01T07:00:00Z","date_published":"2018-05-01T07:00:00Z","updated_at":"2026-07-24T00:59:24Z","subjects":["Cellular Dehydration","Glucose Regulation","Vasopressin","Endocrinology, Diabetes, and Metabolism","Microbial Physiology","Systems and Integrative Physiology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarworks.uark.edu/etd/2760","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Ganio, Matthew S.","Washington, Tyrone A."]},{"key":"dc:contributor.advisor","label":"Advisor","values":["Kavouras, Stavros A."]},{"key":"dc:creator","label":"Author","values":["Yang, Chunbo"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2018"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2020-06-11T07:00:00Z"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science in Kinesiology (MS)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Cellular Dehydration","Glucose Regulation","Vasopressin","Endocrinology, Diabetes, and Metabolism","Microbial Physiology","Systems and Integrative Physiology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarworks.uark.edu/etd/2760"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["A chronically elevated vasopressin level has been associated with an impaired glucose regulation system in humans. A recent study in patients with diabetes suggested that low water intake is associated with impaired glucose regulation. The aim of this study was to examine the effect of hypertonic saline infusion on glucose regulation in healthy females. Thirty healthy, non-diabetic females performed a 2-h infusion followed by a 4-h oral glucose tolerance test (OGTT). Every subject participated in two trials separated by one month, in a counterbalanced order. Two trials were identical in the procedure, differing in the concentration of saline infusion, with one trial being 3% NaCl (HYPER), another being 0.9% NaCl (ISO). The HYPER trial led to an increase in plasma osmolality (time point 0 min, 305±0.91 vs. 287±0.61 mmol/kg, P
"]},{"key":"dc:title","label":"Title","values":["The Effect of Cellular Dehydration on Glucose Regulation in Lean and Obese Females"]}]}],"canonical_facts":{"dc:contributor":["Ganio, Matthew S.","Washington, Tyrone A."],"dc:contributor.advisor":["Kavouras, Stavros A."],"dc:creator":["Yang, Chunbo"],"dc:date":["2018"],"dc:date.available":["2020-06-11T07:00:00Z"],"dc:description.abstract":["A chronically elevated vasopressin level has been associated with an impaired glucose regulation system in humans. A recent study in patients with diabetes suggested that low water intake is associated with impaired glucose regulation. The aim of this study was to examine the effect of hypertonic saline infusion on glucose regulation in healthy females. Thirty healthy, non-diabetic females performed a 2-h infusion followed by a 4-h oral glucose tolerance test (OGTT). Every subject participated in two trials separated by one month, in a counterbalanced order. Two trials were identical in the procedure, differing in the concentration of saline infusion, with one trial being 3% NaCl (HYPER), another being 0.9% NaCl (ISO). The HYPER trial led to an increase in plasma osmolality (time point 0 min, 305±0.91 vs. 287±0.61 mmol/kg, P
"],"dc:identifier":["https://scholarworks.uark.edu/etd/2760"],"dc:subject":["Cellular Dehydration","Glucose Regulation","Vasopressin","Endocrinology, Diabetes, and Metabolism","Microbial Physiology","Systems and Integrative Physiology"],"dc:title":["The Effect of Cellular Dehydration on Glucose Regulation in Lean and Obese Females"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science in Kinesiology (MS)"]},"updated_at":"2026-07-24T00:59:24Z"}