Abstract
dc:description.abstract<p>Group B saponins, the predominant form of saponins in heat-treated soy products, have been shown to possess hypocholesterolemic, antimutagenic, and anticarcinogenic properties. Previous studies have evaluated crude mixtures of soyasaponins, but studies evaluating a single purified soyasaponin as an anticarcinogenic agent are limited. The goal of this study is to examine the effects of purified soyasaponins I and III as well as their aglycone form, soyasapogenol B, as anticarcinogenic agents on the human colon adenocarcinoma cell line Caco-2. Experiments were conducted to determine the effects of purified soyasaponins on cell proliferation, Protein Kinase C (PKC) activity, and cell morphology in cultures of Caco-2 cells. Treatment of cells with soyasaponins I and III at concentrations of 300-900 ppm significantly reduced viable cell numbers after 48 and 72 hours of exposure by 10-35% (p</p>
Degree
thesis:*- Name thesis:degree_name
- Master of Science in Food Science (MS)
- Level thesis:degree_level
- Thesis
- Year dc:date.available
- 2011
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Salyer, Joseph Tyler
- Advisor dc:contributor.advisor
-
- Lee, Sun-Ok
- Contributors dc:contributor
-
- Chen, Pengyin
- Devareddy, Latha
Subjects
dc:subject × 7Identifiers
dc:identifier.*- Repository record dc:identifier
- https://scholarworks.uark.edu/etd/257
- OAI identifier oai:identifier
- oai:scholarworks.uark.edu:etd-1256